Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases
Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases
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DOI：
10.1016/j.brainresbull.2018.11.017
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Nai-hong Chen
中科院分区：
文献类型：
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作者：
Piao Luo;Shi-feng Chu;Zhao Zhang;Cong-yuan Xia;Nai-hong Chen
Fractalkine (CX3C chemokine ligand 1, CX3CL1) is an essential chemokine, for regulating adhesion and chemotaxis through binding to CX3CR1, which plays a critical role in the crosstalk between glial cells and neurons by direct or indirect ways in the central nervous system (CNS). Fractalkine/CX3CR1 axis regulates microglial activation and function, neuronal survival and synaptic function by controlling the release of inflammatory cytokines and synaptic plasticity in the course of the neurological disease. The multiple functions of fractalkine/CX3CR1 make it exert neuroprotective or neurotoxic effects, which determines the pathogenesis. However, the role of fractalkine/CX3CR1 in the CNS remains controversial. Whether it can be used as a therapeutic target for neurological diseases needs to be further investigated. In this review, we summarize the studies highlighting fractalkine/CX3CR1-mediated effects and discuss the potential neurotoxic and neuroprotective actions of fractalkine/CX3CR1 in brain injury for providing useful insights into the potential applications of fractalkine/CX3CR1 in neurological diseases.
