Electrophysiologic and hemodynamic effects of a single oral dose of pilsicainide hydrochloride, a new class 1c antiarrhythmic agent.
Electrophysiologic and hemodynamic effects of a single oral dose of pilsicainide hydrochloride, a new class 1c antiarrhythmic agent.
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单剂量口服盐酸匹西卡尼（一种新型 1c 类抗心律失常药）的电生理和血流动力学影响。
DOI：
10.1097/00005344-199801000-00021
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发表时间：
1998
影响因子：
3
通讯作者：
H. Hayakawa
中科院分区：
文献类型：
--
作者：
T. Ino;H. Atarashi;A. Kuruma;T. Onodera;H. Saitoh;H. Hayakawa
为确定匹西卡胺的临床疗效，我们对18例确诊的室上性心动过速(SVT)患者单次口服匹西卡胺后，对其电生理和血流动力学的影响进行了评估。为了确定最低有效血药浓度，通过静脉采血测定血浆匹西卡胺浓度的一系列再诱导研究，评估了药效随时间的变化。单次口服匹西卡胺60min后，窦房传导时间、AH间期、HV间期及右室有效不应期均延长。11例患者的室房传导受阻，其中9例为旁道，6例为房室结，9例为室性心动过速。在60min时，吡西卡胺增加心率和平均肺动脉压，降低每搏输出量指数。匹西卡胺治疗后PQ间期、QRS宽度和QTc值显著延长，且PQ间期延长的百分比与血浆匹西卡胺浓度呈正相关。抑制SVT的有效血药浓度为0.5微克/毫升。我们得出结论，单次口服匹西卡胺对SVT有良好的耐受性和有效的抑制作用。
To establish the clinical efficacy of pilsicainide, we evaluated its electrophysiologic and hemodynamic effects after a single oral administration to 18 patients with documented supraventricular tachycardia (SVT). To determine the minimal effective blood level, changes in efficacy with time were evaluated by serial reinduction studies with venous blood sampling for measurement of the plasma pilsicainide level. Sixty minutes after administration of a single oral dose of pilsicainide, the sinoatrial conduction time, AH and HV intervals, and the effective refractory period of the right ventricle were prolonged. Ventriculoatrial conduction was blocked in 11 patients [nine of 12 via accessory pathway and two of six via the atrioventricular (AV) node], resulting in the suppression of SVT induction in nine of 13 patients. Pilsicainide increased the heart rate and mean pulmonary arterial pressure and decreased the stroke volume index at 60 min. PQ interval, QRS width, and QTc were significantly prolonged after pilsicainide, and the percentage prolongations of the PQ interval were well correlated with the plasma pilsicainide levels. The plasma level effective for suppression of SVT was considered to be >0.5 microg/ml. We concluded that a single oral administration of pilsicainide is well tolerated and effective in suppressing SVT.
DOI：
10.1056/nejm198908103210629
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
--
作者：
W. Rogers;A. Epstein;J. Arciniegas;S. M. Dailey;G. Kay;R. Little;W. Maclean;S. Papapietro
通讯作者：
W. Rogers;A. Epstein;J. Arciniegas;S. M. Dailey;G. Kay;R. Little;W. Maclean;S. Papapietro
Ic类抗心律失常药的负性肌力作用机制：氟卡尼和匹西卡尼对狗心室肌细胞内钙处理影响的比较研究。
影响因子：
3
作者：
Y. Kihara;M. Inoko;N. Hatakeyama;Y. Momose;S. Sasayama
通讯作者：
S. Sasayama