FUNCTIONAL-ANALYSIS OF CIRCADIAN PACEMAKERS IN NOCTURNAL RODENTS .1. STABILITY AND LABILITY OF SPONTANEOUS FREQUENCY
FUNCTIONAL-ANALYSIS OF CIRCADIAN PACEMAKERS IN NOCTURNAL RODENTS .1. STABILITY AND LABILITY OF SPONTANEOUS FREQUENCY
复制标题
DOI：
10.1007/bf01417856
复制
发表时间：
1976-01-01
期刊：
影响因子：
--
通讯作者：
DAAN, S
中科院分区：
文献类型：
--
作者：
PITTENDRIGH, CS;DAAN, S
昼夜节律起搏器控制4个物种的活动节律。在恒定的黑暗中，比较了啮齿动物[金色中蜂、白斑拟青霉、黑线拟青霉和小鼠]的自由运行系统。在分析它们的稳定性时，区分了自发的日常频率不稳定和可追溯到已确定原因的较长期不稳定。起搏器的精度(日间稳定性)S周期[？]大约是HIVIN..tau的两倍(估计SD=0.6%。在小鼠肌肉中)，因为它驱动的活动节奏已经非常精确(平均SD=1.2%的组氨酸...tau。[平均起搏周期])。可识别的长期不稳定的原因包括年龄和先前被光夹带的几个特征。光周期的周期和光周期对tau有可预见的影响；它们会引起后遗症。在自由运行系统中引起相移的单个光脉冲也是如此。持续的光也有与长光周期的后效相反的后效。骨骼光周期的后效应支持这样的假设，即光到暗的转变参与了夹带过程，这导致了tau的变化。日常不稳定和长期不稳定在其**图形**的物种(Permyscus manulatus，Mus Musculus)中最为明显。[物种平均]比24小时短得多；它们在仓鼠中最不明显，它的**图表**。接近24小时的时间是难以区分的。起搏器不稳定的程度与起搏器不稳定的不同是平行的，起搏器不稳定的程度是通过光诱导的后遗症和随年龄变化的程度来衡量的。这两个物种在紧密性上明显不同。在稳态上是保守的。
The circadian pacemakers controlling activity rhythms in 4 spp. of rodents [Mesocricetus auratus, Peromyscus leucopus, P. maniculatus and Mus musculus] are compared, as freerunning systems in constant darkness. In analyzing their stability the distinction is made between spontaneous day-to-day instability of frequency and a longer-term lability, traceable to identified causes. The precision (day-to-day stability) of the pacemaker''s period [.tau.] is about twice as good (estimated SD = 0.6% of .hivin..tau. in Mus musculus) as the already remarkable precision of the activity rhythm it drives (average SD = 1.2% of .hivin..tau. [average pacemaker period]). Identifiable causes of long-term lability include age and several features of prior entrainment by light. The period and photoperiod of a light cycle have a predictable influence on .tau.; they cause after-effects. So do single light pulses causing a phase-shift in the freerunning system. Constant light also has an after-effect opposite in sign from the after-effect of long photoperiods. After-effects of skeleton photoperiods support the hypothesis that the transitions of light to darkness are involved in the entrainment process which leads to changes in .tau.. Both day-to-day instability and long term lability are most pronounced in species (Peromyscus maniculatus, Mus musculus) whose .**GRAPHIC**. [species average] is considerably shorter than 24 h; they are least pronounced in hamsters whose .**GRAPHIC**. is indistinguishably close to 24 h. The differences between the species in .tau. and its lability are paralleled by differences in pacemaker lability as measured in light-induced after-effects and in the extent of changes with age. The species evidently differ in the tightness with which .tau. is homeostatically conserved.