INTERSTITIAL MURINE CYTOMEGALO-VIRUS PNEUMONIA AFTER IRRADIATION - CHARACTERIZATION OF CELLS THAT LIMIT VIRAL REPLICATION DURING ESTABLISHED INFECTION OF THE LUNGS
INTERSTITIAL MURINE CYTOMEGALO-VIRUS PNEUMONIA AFTER IRRADIATION - CHARACTERIZATION OF CELLS THAT LIMIT VIRAL REPLICATION DURING ESTABLISHED INFECTION OF THE LUNGS
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DOI：
10.1128/jvi.55.2.264-273.1985
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发表时间：
1985-01-01
影响因子：
5.4
通讯作者：
KOSZINOWSKI, UH
中科院分区：
文献类型：
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作者：
REDDEHASE, MJ;WEILAND, F;KOSZINOWSKI, UH
在全身γ-巨细胞病毒感染后观察到与肺组织中病毒复制相关的间质性肺炎。然而，在未受损的宿主中，肺不受影响，病毒增殖仅限于唾液腺。辐射损伤可能会使通常不允许的细胞类型易于发生生产性感染，或者通过消除淋巴细胞来消除对感染组织表现的免疫控制。将淋巴细胞连续转移到受照射的受者中，支持第二种选择。即使在肺中建立了感染，如肺泡隔中存在受感染的肺组织细胞所示，抗病毒作用也可以归因于免疫活性供体中特异性致敏的T淋巴细胞的Lyt-2+，L3 T4-亚群。这些细胞不需要在体外增殖，在体内执行效应细胞的功能，并在生理条件下，在相对较低的数字操作。因此，有理由假设T淋巴细胞负责感染期间巨细胞病毒复制的组织分布。
Interstitial pneumonia associated with viral replication in lung tissue was observed after cytomegalovirus infection of total-body .gamma.-irradiated mice, whereas in noncompromised hosts, the lungs were not affected and virus multiplication was restricted to the salivary glands. The radiation damage could either predispose normally nonpermissive cell types for productive infection or abrogate an immune control of the tissue manifestation of infection by elimination of lymphocytes. Adoptive transfer of lymphoid cells into irradiated, infected recipients supported the 2nd alternative. Even when infection was established in the lungs, as manifested by the presence of infected lung tissue cells in the alveolar septa, an antiviral effect could be assigned to the Lyt-2+, L3T4- subset of T lymphocytes specifically sensitized in the immunocompetent donor. These cells did not require in vitro propagation to perform effector cell functions in vivo and were operative under physiological conditions in comparatively low numbers. Thus, there is reason to assume that T lymphocytes are responsible for the tissue distribution of cytomegalovirus replication during infection.