Modeling and analysis of a virus that replicates selectively in tumor cells
Modeling and analysis of a virus that replicates selectively in tumor cells
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DOI：
10.1006/bulm.2001.0245
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发表时间：
2001-07-01
影响因子：
3.5
通讯作者：
Wein, LM
中科院分区：
文献类型：
--
作者：
Wu, JT;Byrne, HM;Wein, LM
具有复制能力的病毒在克服传统基因治疗癌症治疗方法所经历的低效基因转导方面显示出了巨大的希望。这些病毒感染肿瘤细胞并在其中复制，最终导致裂解。裂解过程中释放的病毒颗粒随后能够感染其他特纳细胞，这样，连续几轮的感染和裂解使病毒能够扩散到整个肿瘤。受这种新型癌症治疗方法的启发，我们制定并分析了一个偏微分方程组，该方程组本质上是嵌入 Stefan 问题的径向对称流行病模型。我们比较了三种替代病毒注射策略：将预先感染病毒的固定部分细胞引入整个肿瘤体积、肿瘤核心内或肿瘤边缘内。对于所有三种注射方法，都得出了预测病毒是否会控制肿瘤的简单而准确的条件。 (C) 2001 年数学生物学学会。
Replication-competent viruses have shown considerable promise in overcoming the inefficient gene transduction experienced by traditional gene therapy approaches to cancer treatment. The viruses infect tumor cells and replicate inside them, eventually causing lysis. Virus particles released during lysis are then able to infect other turner cells, and, in this way, continuous rounds of infection and lysis allow the virus to spread throughout the tumor. Motivated by this novel cancer treatment, we formulate and analyse a system of partial differential equations that is essentially a radially-symmetric epidemic model embedded in a Stefan problem. We compare three, alternative virus-injection strategies: a fixed fraction of cells pre-infected with the virus are introduced throughout the entire tumor volume, within the tumor core, or within the tumor rim. For all three injection methods, simple and accurate conditions that predict whether the virus will control the tumor are derived. (C) 2001 Society for Mathematical Biology.