Effects of Short-Term Synaptic Plasticity in a Local Microcircuit on Cell Firing
Effects of Short-Term Synaptic Plasticity in a Local Microcircuit on Cell Firing
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DOI：
10.1016/s0925-2312(02)00757-9
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发表时间：
2002-02
期刊：
影响因子：
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通讯作者：
David Eriksson;E. Fransén;Y. Zilberter;A. Lansner
中科院分区：
文献类型：
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作者：
David Eriksson;E. Fransén;Y. Zilberter;A. Lansner
在生物物理模型中，分析了短期突触可塑性对相互连接的锥体细胞和新皮质2/3层FSN中间神经元组成的微电路中细胞放电特性的影响。通过反向传播树突动作电位诱导突触抑制，以及由此导致的IPSP幅度的时间依赖性抑制被复制。结果表明，当输入频率超过30 Hz时，凹陷的影响变得明显。影响的大小取决于树枝状钙调节抑郁的时间常数。频率范围取决于IPSP的时间常数。
Effects of short-term synaptic plasticity on cell firing properties in a microcircuit formed by a reciprocally connected pyramidal cell and FSN interneuron in layer 2/3 of neocortex were analyzed in a biophysical model. Induction of synaptic depression by backpropagating dendritic action potentials was replicated, as well as the resulting time dependent depression of IPSP amplitudes. Results indicate that the effect of the depression becomes significant above 30 Hz input frequency. The magnitude of the effect depends on the time constant of the dendritic calcium regulating the depression. The frequency range depends on the time constant of the IPSP.