Callosal Disconnection Syndrome after Corpus Callosum Infarct: A Diffusion Tensor Tractography Study
Callosal Disconnection Syndrome after Corpus Callosum Infarct: A Diffusion Tensor Tractography Study
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DOI：
10.1016/j.jstrokecerebrovasdis.2012.10.015
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发表时间：
2013-10-01
影响因子：
2.5
通讯作者：
Chang, Min Cheol
中科院分区：
文献类型：
--
作者：
Jang, Sung Ho;Lee, Jun;Chang, Min Cheol
我们报告了一位患者，在胼胝体梗死(CC)后，在弥散张量束成像(DTT)上表现为穹隆断连综合征(CDS)和纤维断连。患者为72岁女性，主要表现为额部异手综合征(AHS)、左侧失写、右侧偏瘫、右侧躯体感觉障碍、左侧忽视和视觉识别障碍。对CC纤维进行DTT检查，并与正常人的DTT检查结果进行比较。正常受试者的DTT显示CC纤维双侧延伸至额叶、顶叶和枕颞叶皮质。相比之下，患者的CC纤维显示出广泛的断裂，但穿过前膝和后压部的CC纤维除外。CC纤维的广泛破坏似乎可以解释患者的各种CDS症状。总之，DTT可用于CDS患者CC病变的检测。
We report a patient who presented with callosal disconnection syndrome (CDS) and fiber disconnection on diffusion tensor tractography (DTT) after an infarct of the corpus callosum (CC). A 72-year-old woman presented with manifestations of CDS, including frontal alien hand syndrome (AHS), left agraphia, right hemiparesis, right somatosensory deficit, left neglect, and impaired visual recognition. DTT was performed for the evaluation of CC fibers, followed by comparison with DTT findings of normal subjects. DTT of the normal subject revealed bilateral extension of CC fibers to the frontal, parietal, and occipitotemporal cortices. By contrast, CC fibers of the patient revealed extensive disruption, with the exception of CC fibers passing through the anterior genu and the posterior splenium. The extensive disruption of CC fibers appears to explain the patient's various CDS symptoms. In brief, DTT could be useful for detection of CC lesions in patients with CDS.