Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review.
Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review.
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DOI：
10.1371/journal.pone.0174847
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Boe SG
中科院分区：
文献类型：
--
作者：
McInnes K;Friesen CL;MacKenzie DE;Westwood DA;Boe SG
轻度创伤性脑损伤（mTBI）或脑震荡是最常见的创伤性脑损伤类型。mTBI的症状包括头痛、疲劳、抑郁、焦虑和易怒，以及认知功能受损。症状消退被认为在受伤后3个月内发生，除了一小部分人据说经历持续的脑震荡后综合征。尽管有明确证据表明mTBI导致长期病理生理变化，但经历持续症状的个体数量似乎很低。鉴于脑病理学的这些长期变化与长期mTBI相关症状（特别是认知功能受损）的个体数量之间的不一致性，我们对文献进行了范围审查，对单一mTBI个体的短期和长期认知功能进行了行为评估，目的是确定单一脑震荡对损伤后慢性阶段认知功能的影响。我们于2015年7月检索了CINAHL、Embase和Medline/Ovid关于脑震荡和认知障碍的研究。从符合纳入标准的45项研究中提取与认知障碍存在/不存在相关的数据。结果表明，与大多数脑震荡症状在损伤后3个月内消退的普遍观点相反，大约一半的单次mTBI患者表现出长期认知障碍。尽管研究存在局限性，但这些发现强调了仔细检查单一mTBI的长期影响的必要性。
Mild traumatic brain injury (mTBI), or concussion, is the most common type of traumatic brain injury. With mTBI comes symptoms that include headaches, fatigue, depression, anxiety and irritability, as well as impaired cognitive function. Symptom resolution is thought to occur within 3 months post-injury, with the exception of a small percentage of individuals who are said to experience persistent post-concussion syndrome. The number of individuals who experience persistent symptoms appears to be low despite clear evidence of longer-term pathophysiological changes resulting from mTBI. In light of the incongruency between these longer-term changes in brain pathology and the number of individuals with longer-term mTBI-related symptoms, particularly impaired cognitive function, we performed a scoping review of the literature that behaviourally assessed short- and long-term cognitive function in individuals with a single mTBI, with the goal of identifying the impact of a single concussion on cognitive function in the chronic stage post-injury. CINAHL, Embase, and Medline/Ovid were searched July 2015 for studies related to concussion and cognitive impairment. Data relating to the presence/absence of cognitive impairment were extracted from 45 studies meeting our inclusion criteria. Results indicate that, in contrast to the prevailing view that most symptoms of concussion are resolved within 3 months post-injury, approximately half of individuals with a single mTBI demonstrate long-term cognitive impairment. Study limitations notwithstanding, these findings highlight the need to carefully examine the long-term implications of a single mTBI.