Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity.
Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity.
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DOI：
10.1371/journal.pone.0054600
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gude F
中科院分区：
文献类型：
--
作者：
Gonzalez-Quintela A;Alonso M;Campos J;Vizcaino L;Loidi L;Gude F
脂多糖 (LPS) 结合蛋白 (LBP) 的血清浓度评估被认为是一种有用的生物标志物，可指示对微生物产物的先天免疫反应的激活。我们研究了成人 LBP 浓度及其与人口统计、生活方式因素和常见代谢异常的关系。我们还检查了 LBP 浓度是否与编码 LBP (rs2232618)、CD14 (rs2569190) 和 TLR4 (rs4986790) 的基因的常见多态性相关，这些基因负责对 LPS 的先天免疫反应，或可溶性 CD14 (sCD14) 和促炎细胞因子的血清水平。使用商业免疫测定法对来自单个城市的成年人群（n = 420，45％男性，年龄 18-92 岁）的随机样本测量血清 LBP。血清LBP浓度随着年龄的增长而增加（P<0.001），并且超重或肥胖个体的浓度高于正常体重个体（P<0.001）。同样，患有代谢综合征的个体的 LBP 浓度高于没有代谢综合征的个体（P<0.001）。在代谢综合征的组成部分中，LBP 浓度与腹部肥胖 (P = 0.002) 和低 HDL 胆固醇浓度 (P<0.001) 独立相关。血清 LBP 浓度往往与吸烟独立相关 (P = 0.05)，但与饮酒无关。同样，LBP 浓度与基因多态性之间也没有显着关联。 LBP 浓度与促炎细胞因子（IL-6 和 IL-8）、sCD14 和肝酶的血清水平显着相关。血清 LBP 浓度随着年龄的增长而增加。超重、肥胖和代谢综合征（特别是低 HDL 胆固醇水平）与较高的 LBP 浓度相关。这些发现与微生物暴露在这些炎症、代谢异常中发挥的作用是一致的。
Assessment of serum concentration of lipopolysaccharide (LPS)-binding protein (LBP) has been suggested as a useful biomarker to indicate activation of innate immune responses to microbial products. We investigated LBP concentrations and associations with demographics, lifestyle factors, and common metabolic abnormalities in adults. We also examined if LBP concentrations were associated with common polymorphisms in genes coding for LBP (rs2232618), CD14 (rs2569190), and TLR4 (rs4986790), the molecules responsible for the innate immune response to LPS, or serum levels of soluble CD14 (sCD14) and proinflammatory cytokines. Serum LBP was measured with a commercial immunoassay in a random sample of the adult population (n = 420, 45% males, age 18–92 years) from a single municipality. Serum LBP concentrations increased with age (P<0.001) and were higher in individuals who were overweight or obese than in normal-weight individuals (P<0.001). Similarly, LBP concentrations were higher in individuals with metabolic syndrome than in individuals without it (P<0.001). Among metabolic syndrome components, LBP concentrations were independently associated with abdominal obesity (P = 0.002) and low concentrations of HDL-cholesterol (P<0.001). Serum LBP concentrations tended to be independently associated with smoking (P = 0.05), but not with alcohol consumption. Likewise, there was not significant association between LBP concentrations and gene polymorphisms. Concentrations of LBP significantly correlated with serum levels of proinflammatory cytokines (IL-6 and IL-8), sCD14, and with liver enzymes. Serum LBP concentrations increased with age. Overweight, obesity, and having metabolic syndrome (particularly, low HDL cholesterol levels) were associated with higher LBP concentrations. These findings are consistent with microbial exposure playing a role in these inflammatory, metabolic abnormalities.
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影响因子：
16.2
作者：
Ghanim H;Abuaysheh S;Sia CL;Korzeniewski K;Chaudhuri A;Fernandez-Real JM;Dandona P
通讯作者：
Dandona P
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
6.8
作者：
Gonzalez-Quintela, Arturo;Vizcaino, Luis;Vidal, Carmen
通讯作者：
Vidal, Carmen
DOI：
10.1111/j.1530-0277.2006.00007.x
发表时间：
2006-01-01
影响因子：
3.2
作者：
Campos, J;Gude, F;Gonzalez-Quintela, A
通讯作者：
Gonzalez-Quintela, A
DOI：
10.1097/01.alc.0000171977.25531.7a
发表时间：
2005-07-01
影响因子：
3.2
作者：
Campos, J;Gonzalez-Quintela, A;Vidal, C
通讯作者：
Vidal, C