Clinical significance of microRNA-155 expression in hepatocellular carcinoma
Clinical significance of microRNA-155 expression in hepatocellular carcinoma
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DOI：
10.3892/ol.2015.4048
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发表时间：
2016-02-01
期刊：
影响因子：
2.9
通讯作者：
Xu, Meng
中科院分区：
文献类型：
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作者：
Guan, Chengnong;Yang, Feng;Xu, Meng
本研究旨在评估肝细胞癌（HCC）和癌旁正常组织中微小RNA-155（miR-155）的表达，并评估其与该肿瘤类型临床病理特征的相关性。使用荧光逆转录定量聚合酶链反应 (RT-qPCR) 在 40 个 HCC 组织样本和 40 个邻近无肿瘤组织样本中检测到 miR-155 表达。分析了 HCC 和邻近正常组织样本中 miR155 表达、临床病理特征和 1 年无复发生存率 (RFS) 之间的关联。 RT-qPCR结果显示，25例（62.5%）肝癌组织中miR-155表达水平较癌周组织中观察到的表达水平显着升高（P
The present study aimed to evaluate the expression of microRNA-155 (miR-155) in hepatocellular carcinoma (HCC) and adjacent normal tissues, and assess its correlation with clinicopathological characteristics of this tumor type. miR-155 expression was detected in 40 HCC tissue samples and 40 samples of adjacent tumor-free tissue using fluorescent reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The association between miR155 expression, clinicopathological features and 1-year relapse-free survival (RFS) in HCC and adjacent normal tissue samples was analyzed. RT-qPCR results revealed that, in 25 cases (62.5%), miR-155 expression levels were significantly increased in HCC tissues compared with the expression levels observed in pericarcinomatous tissues (P