Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.
Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.
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DOI：
10.1016/j.phytol.2018.11.021
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发表时间：
2019-02-01
影响因子：
1.7
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Yang, Beiye;Tong, Qingyi;Zhang, Yonghui
植物内生真菌拟盘拟盘菌的化学研究。提供了两种新的丁烯内酯，Pestalolides B 和 C（1 和 2），两种新的二苯醚，Pestalotethers E 和 F（3 和 4），以及七种已知化合物（5-11）。它们的结构通过广泛的光谱分析确定，并且1的绝对构型通过ECD计算进一步确认。在结构上，化合物 1 代表了新型丁烯内酯衍生物的第一个例子，具有前所未有的具有 13 个碳原子的碳支架。评估化合物1-4的细胞毒活性，化合物1对人肿瘤HL60、U87MG、MDA-MB-231和HEP-3B细胞系显示出显着的抑制效力，IC50值分别为1.42、5.90、5.90和4.29μM。
Chemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5-11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compound 1 represents the first example of a new type of butenolide derivatives, bearing an unprecedented carbon scaffold having 13 carbon atoms. Compounds 1-4 were evaluated for the cytotoxic activities, and compound 1 showed remarkable inhibitory potency against human tumor HL60, U87MG, MDA-MB-231, and HEP-3B cell lines, with IC50, values of 1.42, 5.90, 5.90, and 4.29 mu M, respectively.