α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking
α-Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking
复制标题
DOI：
10.1073/pnas.1117190108
复制
发表时间：
2011-11-29
影响因子：
11.1
通讯作者：
Jensen, Ole
中科院分区：
文献类型：
--
作者：
Haegens, Saskia;Nacher, Veronica;Jensen, Ole
在人类中使用磁学和脑电图学的广泛研究有力地表明，振荡α活动(8-14赫兹)的减少促进了给定区域的处理，而α活动的增加则积极地抑制了无关或干扰的处理。然而，关于α-活动如何与神经元放电有关的研究工作还很少。在这里，当一只训练有素的猴子执行振动触觉辨别任务时，我们同时记录了来自躯体感觉、运动前和运动区的局部场电位和棘波。在局部场电位中，我们观察到阿尔法频段有很强的活动，在辨别任务中感觉运动区的活动有所减少。这种阿尔法功率的降低预示着更好的辨别性能。此外，阿尔法振荡表现出与尖峰的节律性关系，因此，在阿尔法周期的低谷，放电最高。射击速度随着阿尔法威力的降低而增加。这些发现表明，阿尔法振荡对脉冲计时和放电频率都有很强的抑制作用。因此，阿尔法振荡的脉冲抑制在扩展感觉运动系统中起着重要的作用。
Extensive work in humans using magneto-and electroencephalography strongly suggests that decreased oscillatory alpha-activity (8-14 Hz) facilitates processing in a given region, whereas increased a-activity serves to actively suppress irrelevant or interfering processing. However, little work has been done to understand how a-activity is linked to neuronal firing. Here, we simultaneously recorded local field potentials and spikes from somatosensory, premotor, and motor regions while a trained monkey performed a vibrotactile discrimination task. In the local field potentials we observed strong activity in the alpha-band, which decreased in the sensorimotor regions during the discrimination task. This alpha-power decrease predicted better discrimination performance. Furthermore, the alpha-oscillations demonstrated a rhythmic relation with the spiking, such that firing was highest at the trough of the alpha-cycle. Firing rates increased with a decrease in alpha-power. These findings suggest that alpha-oscillations exercise a strong inhibitory influence on both spike timing and firing rate. Thus, the pulsed inhibition by alpha-oscillations plays an important functional role in the extended sensorimotor system.