Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report
Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report
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鼻腔上皮肌上皮癌：病例报告的临床、组织病理学和免疫组织化学鉴别
DOI：
10.1177/1066896917747732
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发表时间：
2018
影响因子：
1.2
通讯作者：
Marie
中科院分区：
文献类型：
--
作者：
Sally Nguyen;Marjorie Perron;Sylvie Nadeau;A. Odashiro;Marie
背景。上皮性肌上皮癌（EMCs）是罕见的低级别唾液腺肿瘤。在此，我们报告一个75岁男性的病例，表现为鼻腔EMC的嗜瘤细胞变异型，最初诊断为嗜瘤细胞瘤。方法。我们的患者于2012年接受了功能性鼻窦手术。病理上，在右鼻腔发现一嗜瘤细胞肿瘤，其特征是均匀的淡色嗜瘤细胞碎片，细胞核呈双层排列。免疫组化染色显示双相细胞：管腔上皮细胞和基底细胞型肌上皮细胞。肿瘤被诊断为嗜瘤细胞瘤。2015年，患者再次出现右下鼻甲病变，符合嗜瘤性EMC。结果。患者接受肿瘤手术和辅助放疗。无疾病复发。结论。存在不同类型的EMC，如嗜瘤细胞型EMC。EMCs应积极治疗，因为它们可能局部侵袭，复发，并引起远处转移。
Background. Epithelial myoepithelial carcinomas (EMCs) are rare low-grade salivary gland tumors. Here, we report the case of a 75-year-old man presenting with an oncocytic variant of EMC of the nasal cavity, initially diagnosed as an oncocytoma. Methods. Our patient underwent functional sinus surgery in 2012. On pathology, an oncocytic neoplasm was found in the right nasal cavity, characterized by fragments of uniform bland oncocytic cells with bilayered arrangement of nuclei. Immunohistochemical stains demonstrated biphasic cells: luminal epithelial and basal cell–type myoepithelial cells. The tumor was best diagnosed as an oncocytoma. In 2015, the patient presented with a recurrent right inferior turbinate lesion, compatible with oncocytic EMC. Results. The patient underwent oncological surgery and received adjuvant radiotherapy. He had no disease recurrence. Conclusion. Different variants of EMCs exist, such as oncocytic EMC. EMCs should be treated aggressively because they can be locally invasive, recur, and give rise to distant metastases.
影响因子：
1.7
作者：
Yamanegi, Koji;Uwa, Nobuhiro;Nakasho, Keiji
通讯作者：
Nakasho, Keiji