Functional circuits mediating sensorimotor integration: Quantitative comparisons of projections from rodent barrel cortex to primary motor cortex, neostriatum, superior colliculus, and the pons
Functional circuits mediating sensorimotor integration: Quantitative comparisons of projections from rodent barrel cortex to primary motor cortex, neostriatum, superior colliculus, and the pons
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DOI：
10.1002/cne.20579
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发表时间：
2005-07-18
影响因子：
2.5
通讯作者：
Alloway, KD
中科院分区：
文献类型：
--
作者：
Hoffer, ZS;Arantes, HB;Alloway, KD
运动表现取决于躯体感觉反馈，并且与这一发现一致，初级躯体感觉（SI）皮层投射到涉及运动控制的几个区域。虽然介导感觉运动整合的途径是已知的，很少有研究比较他们的投影模式。因此，在每只动物中，我们将两种顺行示踪剂注射到Si桶皮质中，并比较标记的投射到初级运动（MI）皮质、新纹状体、上级丘和基底脑桥的相对密度和空间范围。定量分析表明，这些预测终止最广泛的新纹状体，在MI皮质的程度较小，并支配最少量的神经元在上级丘和脑桥核。脑桥核中的示踪剂重叠明显高于其他三个脑区，并且与上级丘中的重叠密切相关，可能是因为这两个脑区的某些投射代表了相同神经元的侧枝。标记的静脉曲张密度在脑桥最高，在MI最低。作为总标记的比例，标记的终端密集的集群是最普遍的脑桥，不太普遍的新纹状体和上级丘，和最不普遍的MI皮质。这些结果是一致的生理证据表明，强烈的一致性SI桶皮质和小脑在搅拌行为。(c)2005 Wiley-Liss，Inc.
Motor performance depends on somatosensory feedback, and consistent with this finding, primary somatosensory (SI) cortex projects to several regions involved in motor control. Although the pathways mediating sensorimotor integration are known, few studies have compared their projection patterns. Therefore, in each animal, we injected two anterograde tracers into Si barrel cortex and compared the relative density and spatial extent of the labeled projections to the primary motor (MI) cortex, neostriatum, superior colliculus, and basal pons. Quantitative analysis revealed that these projections terminated most extensively in the neostriatum, to a lesser extent in MI cortex, and innervated the least amount of neuropil in the superior colliculus and pontine nuclei. Tracer overlap in the pontine nuclei was significantly higher than in the other three brains regions, and was strongly correlated with overlap in the superior colliculus, presumably because some projections to these two brain regions represent collaterals of the same neurons. The density of labeled varicosities was highest in the pons and lowest in MI. As a proportion of total labeling, densely packed clusters of labeled terminals were most prevalent in the pons, less prevalent in neostriatum and superior colliculus, and least prevalent in MI cortex. These results are consistent with physiological evidence indicating strong coherence between SI barrel cortex and the cerebellum during whisking behavior. (c) 2005 Wiley-Liss, Inc.