Approximations and their consequences for dynamic modelling of signal transduction pathways
Approximations and their consequences for dynamic modelling of signal transduction pathways
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DOI：
10.1016/j.mbs.2006.08.012
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发表时间：
2007-05-01
影响因子：
4.3
通讯作者：
Wolkenhauer, Olaf
中科院分区：
文献类型：
--
作者：
Millat, Thomas;Bullinger, Eric;Wolkenhauer, Olaf
信号转导是细胞将一种信号或刺激转化为另一种信号或刺激的过程。这涉及一系列由蛋白质进行的生化反应。复杂的细胞信号网络的动态响应可以在化学动力学的框架中建模和模拟。化学动力学的数学公式导致一个耦合的微分方程系统。简化可以通过假设和近似来实现。本文提供了一个关键的讨论经常采用的近似信号转导途径的动态建模。我们讨论守恒律的要求，稳态近似，和忽略的组件。我们展示了这些近似如何简化生化网络的数学处理，但我们也展示了完整系统之间的差异（c）2006爱思唯尔公司。All rights reserved.
Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins. The dynamic response of complex cell signalling networks can be modelled and simulated in the framework of chemical kinetics. The mathematical formulation of chemical kinetics results in a system of coupled differential equations. Simplifications can arise through assumptions and approximations. The paper provides a critical discussion of frequently employed approximations in dynamic modelling of signal transduction pathways. We discuss the requirements for conservation laws, steady state approximations, and the neglect of components. We show how these approximations simplify the mathematical treatment of biochemical networks but we also demonstrate differences between the complete system (c) 2006 Elsevier Inc. All rights reserved.