The physiology of corticotropin-releasing hormone deficiency in mice
The physiology of corticotropin-releasing hormone deficiency in mice
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DOI：
10.1016/s0196-9781(01)00385-0
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发表时间：
2001-05-01
期刊：
影响因子：
3
通讯作者：
Majzoub, JA
中科院分区：
文献类型：
--
作者：
Muglia, LJ;Jacobson, L;Majzoub, JA
综述了促肾上腺皮质激素释放激素（CRH）缺陷小鼠的产生和特征。这些研究表明，CRH在垂体肾上腺轴对应激、昼夜节律刺激和糖皮质激素戒断反应中起着重要作用。另外。CRH在局部炎症部位的促炎作用得到了进一步的支持。与此相反，在应激过程中的行为影响，已被归因于CRH行动没有改变CRH缺陷小鼠。CRH缺陷小鼠对压力的正常行为反应强烈表明了其他可能尚未发现的CRH样分子的重要性。(C)2001 Elsevier Science Inc. All rights reserved.
A review of the generation and characterization of corticotropin-releasing hormone (CRH)-deficient mice is presented. The studies summarized demonstrate the central role of CRH in the pituitary adrenal axis response to stress, circadian stimulation, and glucocorticoid withdrawal. Additionally. pro-inflammatory actions of CRH at sites of local inflammation are given further support. In contrast, behavioral effects during stress that had been ascribed to CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress in CRH-deficient mice strongly suggests the importance of other, possibly as yet undiscovered, CRH-like molecules. (C) 2001 Elsevier Science Inc. All rights reserved.