Ethnic-affiliation estimation by use of population-specific DNA markers.
Ethnic-affiliation estimation by use of population-specific DNA markers.
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DOI：
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发表时间：
1997-04
影响因子：
9.8
通讯作者：
M. Shriver;Michael W. Smith;L. Jin;A. Marcini;J. Akey;R. Deka;R. Ferrell
中科院分区：
文献类型：
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作者：
M. Shriver;Michael W. Smith;L. Jin;A. Marcini;J. Akey;R. Deka;R. Ferrell
在过去10年中，DNA分析彻底改变了法医鉴定身份的方法。关于两个人类DNA样本的生物身份的声明现在可以完全自信地做出。虽然DNA标记在区分个体方面非常强大，但大多数标记在区分种族或支持关于个体物理特征的任何陈述方面几乎没有能力。通过检索文献和未发表的等位基因频率数据，我们确定了一组人群特异性遗传标记，可以对美国主要居民人群进行稳健的种族归属估计。在这份报告中，我们确定了这些位点，并提出了他们的水平的等位基因频率之间的差异种族定义的样本，我们证明，使用对数似然分析，这组标记提供了显着的统计能力的种族归属估计。除了在法医种族归属估计中的应用外，群体特异性遗传标记在群体和个体水平的混合估计中以及通过使用群体杂交时产生的连锁不平衡来定位基因中都非常有用。
During the past 10 years, DNA analysis has revolutionized the determination of identity in a forensic context. Statements about the biological identity of two human DNA samples now can be made with complete confidence. Although DNA markers are very powerful for distinguishing among individuals, most offer little power to distinguish ethnicity or to support any statement about the physical characteristics of an individual. Through a search of the literature and of unpublished data on allele frequencies we have identified a panel of population-specific genetic markers that enable robust ethnic-affiliation estimation for major U.S. resident populations. In this report, we identify these loci and present their levels of allele-frequency differential between ethnically defined samples, and we demonstrate, using log-likelihood analysis, that this panel of markers provides significant statistical power for ethnic-affiliation estimation. In addition to their use in forensic ethnic-affiliation estimation, population-specific genetic markers are very useful in both population- and individual-level admixture estimation and in mapping genes by use of the linkage disequilibrium created when populations hybridize.