Dietary Fatty Acid Intake and Prostate Cancer Survival in rebro County, Sweden
Dietary Fatty Acid Intake and Prostate Cancer Survival in rebro County, Sweden
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DOI：
10.1093/aje/kwr520
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发表时间：
2012-08-01
影响因子：
5
通讯作者：
Andren, Ove
中科院分区：
文献类型：
--
作者：
Epstein, Mara M.;Kasperzyk, Julie L.;Andren, Ove
尽管饮食脂肪与前列腺癌风险相关，但特定脂肪酸与前列腺癌存活率之间的关联仍不清楚。瑞布洛县(19891994)525名患有前列腺癌的瑞典男性在人群队列中分析了14种脂肪酸的饮食摄入量。通过COX比例风险回归估计前列腺癌死亡时间的多变量风险比和95个可信区间，以四分位数和每标准差增加摄入量。其他模型在诊断时按阶段检查了这种关联(局部化：T0-T2/M0；高级：T0-T4/M1，T3-T4/M0)。在所有男性中，omega-3二十二碳六烯酸和海洋脂肪酸总摄入量最高的人死于前列腺癌的可能性降低40%(P趋势分别为0.05和0.04)。在患有局限性前列腺癌的男性中，总脂肪增加的风险比为2.07(95可信区间：0.93，4.59；P趋势0.03)，饱和肉豆蔻酸的风险比为2.39(95可信区间：1.06，5.38)，短链(C4-C10)脂肪酸摄入量的风险比为2.88(95可信区间：1.24，6.67)。这项研究表明，总脂肪和某些饱和脂肪酸的高摄入量可能会恶化前列腺癌的存活率，特别是在患有局限性疾病的男性中。相比之下，海洋欧米茄-3脂肪酸的高摄入量可能会提高所有男性的疾病特异性存活率。
Although dietary fat has been associated with prostate cancer risk, the association between specific fatty acids and prostate cancer survival remains unclear. Dietary intake of 14 fatty acids was analyzed in a population-based cohort of 525 Swedish men with prostate cancer in rebro County (19891994). Multivariable hazard ratios and 95 confidence intervals for time to prostate cancer death by quartile and per standard deviation increase in intake were estimated by Cox proportional hazards regression. Additional models examined the association by stage at diagnosis (localized: T0-T2/M0; advanced: T0-T4/M1, T3-T4/M0). Among all men, those with the highest omega-3 docosahexaenoic acid and total marine fatty acid intakes were 40 less likely to die from prostate cancer (P-trend 0.05 and 0.04, respectively). Among men with localized prostate cancer, hazard ratios of 2.07 (95 confidence interval: 0.93, 4.59; P-trend 0.03) for elevated total fat, 2.39 (95 confidence interval: 1.06, 5.38) for saturated myristic acid, and 2.88 (95 confidence interval: 1.24, 6.67) for shorter chain (C4-C10) fatty acid intakes demonstrated increased risk for disease-specific mortality for the highest quartile compared with the lowest quartile. This study suggests that high intake of total fat and certain saturated fatty acids may worsen prostate cancer survival, particularly among men with localized disease. In contrast, high marine omega-3 fatty acid intake may improve disease-specific survival for all men.