Prevalence and clinical characteristics of bipolar I disorder in Butajira, Ethiopia: a community-based study.
Prevalence and clinical characteristics of bipolar I disorder in Butajira, Ethiopia: a community-based study.
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埃塞俄比亚布塔吉拉 I 型双相情感障碍的患病率和临床特征：一项基于社区的研究。
DOI：
10.1016/j.jad.2005.03.011
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发表时间：
2005
影响因子：
6.6
通讯作者：
G. Kullgren
中科院分区：
文献类型：
--
作者：
A. Negash;A. Alem;D. Kebede;N. Deyessa;T. Shibre;G. Kullgren
双相情感障碍在高收入国家已经得到了广泛的研究，但在低收入国家基于社区的研究非常罕见。目前研究的主要目的是估计在埃塞俄比亚Butajira地区的一般人群中双相I型障碍的终生患病率，并描述该疾病在主要为初治人群中的发病和病程。（N= 83，387），其中68，378例成功筛选。第一阶段采用CIDI和关键线人法进行筛查，随后进行确证性SCAN访谈，共确定315例病例，收集到295例完整信息。其中55.3%为男性，83.1%来自农村地区，70.2%为文盲。据估计，双相I型障碍的终生患病率男性为0.6%，女性为0.3%。病例平均年龄为29.5岁，性别差异无统计学意义。首次发现疾病的平均年龄为22.0岁;男性为22.3岁，女性为21.2岁。发现该病躁狂发作期的平均年龄为22.0岁（男性22.5岁，女性21.4岁）。抑郁发作期的平均年龄为23.4岁（男性24.1岁，女性22.5岁）。在躁狂或抑郁阶段的发病年龄上没有显著的性别差异。在22.7%的病例中，双相I型疾病开始于抑郁发作，77.3%的病例开始于躁狂发作。64.1%的人报告了两次或两次以上的疾病发作。超过一半的研究对象（55.9%）从未向现代医疗机构寻求过任何帮助，只有13.2%的人曾入住精神病院。在调查期间，7.1%的病例正在接受治疗。8.1%的男性和5.4%的女性报告了以前的自杀企图。CONCLUSIONThe整体终生患病率和发病年龄在西方国家其他研究结果的范围内。与大多数以前的研究相反，女性中这种疾病的患病率是男性的一半。我们的发现，这种疾病在男性和女性中的患病率似乎与许多其他研究不同，值得进一步研究。
BACKGROUNDBipolar disorders have been extensively studied in the high-income countries but community-based studies from low-income countries are very rare. The main objectives of the current study are to estimate the lifetime prevalence of bipolar I disorder in the general population of the Butajira district in Ethiopia and to characterize the onset and course of the disorder in a predominantly treatment naïve population.METHODCases were identified by a door-to-door screening of the district's entire adult population aged 15 to 49 years (N=83,387), where 68,378 were successfully screened. CIDI and key informant method were used in the first stage of screening followed by confirmatory SCAN interviews.RESULTSThree hundred fifteen cases were identified and complete information could be collected for 295 individuals. Of these, 55.3% were males, 83.1% were from a rural area, and 70.2% were illiterate. Lifetime prevalence of bipolar I disorder was estimated to be 0.6% for males and 0.3% for females. The mean age of cases was 29.5 years, with no significant sex difference. The mean age of first recognition of illness was 22.0 years; for men 22.3 years and for women 21.2 years. The mean age at onset of manic phase of the illness was found to be 22.0 years (22.5 for men and 21.4 for women). The mean age at onset of depressive phase was 23.4 years (24.1 for men and 22.5 for women). There was no significant sex difference in the age of onset of manic or depressive phases. In 22.7% of the cases bipolar I illness started with a depressive episode and in 77.3% of the cases it started with a manic episode. Two or more episodes of the illness were reported by 64.1%. Over half of the study subjects (55.9%) had never sought any help from modern healthcare sector, and only 13.2% had ever been admitted to psychiatric hospital. During the survey 7.1% of the cases were undergoing treatment. A previous suicide attempt was reported by 8.1% of the males and 5.4% of the females.CONCLUSIONThe overall lifetime prevalence and age of onset are within the range of findings from other studies in Western countries. In contrast to most previous studies, prevalence of the disorder among females was half of that among males. Our finding that prevalence of this disorder among males and females appeared to be different from many other studies warrants further research.
波多黎各特定精神疾病的患病率。
影响因子：
--
作者：
Canino,GJ;Bird,HR;Shrout,PE;Rubio-Stipec,M;Bravo,M;Martinez,R;Sesman,M;Guevara,LM
通讯作者：
Guevara,LM