Toward the First Data Acquisition Standard in Synthetic Biology
Toward the First Data Acquisition Standard in Synthetic Biology
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DOI：
10.1021/acssynbio.5b00222
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发表时间：
2016-08-01
影响因子：
4.7
通讯作者：
Kitney, Richard I.
中科院分区：
文献类型：
--
作者：
de Murieta, Inaki Sainz;Bultelle, Matthieu;Kitney, Richard I.
本文介绍了一种新的合成生物学数据采集标准的发展。这包括创建一种旨在捕获与生物部件表征实验相关的所有数据、元数据和方案信息的方法。新标准称为DICOM-SB，基于医学领域非常成功的数字成像和通信（DICOM）标准。描述了一种数据模型，该模型是专门为合成生物学开发的。该模型是一个模块化的，可扩展的数据模型的实验过程中，它可以优化数据存储的大量数据。DICOM-SB还包括面向模态和存储库之间的数据和信息自动交换的服务。DICOM-SB是在合成生物学系统设计的背景下开发的，基于模块化，标准化和表征的工程原理。系统化设计方法利用设计、构建、测试和学习设计周期范例。DICOM-SB被设计为与合成生物学中的其他标准（包括SBOL）兼容和互补。在这方面，该软件提供了有效的互操作性。新标准已通过实验和新加坡南洋理工大学与伦敦帝国理工学院之间的数据交换进行了测试。
This paper describes the development of a new data acquisition standard for synthetic biology. This comprises the creation of a methodology that is designed to capture all the data, metadata, and protocol information associated with biopart characterization experiments. The new standard, called DICOM-SB, is based on the highly successful Digital Imaging and Communications in Medicine (DICOM) standard in medicine. A data model is described which has been specifically developed for synthetic biology. The model is a modular, extensible data model for the experimental process, which can optimize data storage for large amounts of data. DICOM-SB also includes services orientated toward the automatic exchange of data and information between modalities and repositories. DICOM-SB has been developed in the context of systematic design in synthetic biology, which is based on the engineering principles of modularity, standardization, and characterization. The systematic design approach utilizes the design, build, test, and learn design cycle paradigm. DICOM-SB has been designed to be compatible with and complementary to other standards in synthetic biology, including SBOL. In this regard, the software provides effective interoperability. The new standard has been tested by experiments and data exchange between Nanyang Technological University in Singapore and Imperial College London.