Influenza A Virus-Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors.

Influenza A Virus-Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors.
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甲型流感病毒宿主特异性:病毒和宿主因素之间持续的相互作用。

DOI:
10.3389/fmicb.2021.777885
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发表时间:
2021
影响因子:
5.2
通讯作者:
Zhang X
Zhang X
中科院分区:
生物学2区
文献类型:
--
作者:
Zhang M;Liu M;Bai S;Zhao C;Li Z;Xu J;Zhang X

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甲型流感病毒(IAV)的一大威胁是,新病毒在突变的同时还会发生重组。其中一些已经获得了从禽类水库传播到人类的能力。了解打破跨物种屏障的分子事件和涉及的因素对于监测和预防潜在的流感暴发具有重要意义。在这篇综述中,我们总结了最近的进展,包括几个开创性的发现,即宿主和病毒因子之间的相互作用如何塑造IAV从宿主特异性到跨物种感染的进化,例如流感病毒RNA聚合酶PB2亚单位与宿主ANP32蛋白的结合,以促进病毒基因组的转录和复制。
One big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation alongside reassortment. Some of them have gained the capability to transmit into human from the avian reservoir. Understanding the molecular events and the involved factors in breaking the cross-species barrier holds important implication for the surveillance and prevention of potential influenza outbreaks. In this review, we summarize recent progresses, including several ground-breaking findings, in how the interaction between host and viral factors, exemplified by the PB2 subunit of the influenza virus RNA polymerase co-opting host ANP32 protein to facilitate transcription and replication of the viral genome, shapes the evolution of IAVs from host specificity to cross-species infection.
PA-X C 末端的 20 个氨基酸与甲型流感病毒复制和致病性增强相关
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