Delays in neural processing during working memory encoding in normal aging.
Delays in neural processing during working memory encoding in normal aging.
复制标题
正常衰老过程中工作记忆编码过程中神经处理的延迟。
DOI：
10.1016/j.neuropsychologia.2009.08.003
复制
发表时间：
2010
期刊：
影响因子：
2.6
通讯作者：
Gazzaley,Adam
中科院分区：
文献类型：
--
作者：
Zanto,TheodoreP;Toy,Brian;Gazzaley,Adam
神经处理速度的下降被认为是老年人广泛认知缺陷的基础。然而，刺激编码过程中神经加工的延迟对工作记忆的影响尚不清楚。在本研究中，我们评估了年龄对选择性延迟识别任务中处理速度和WM表现之间的神经测量的影响，同时记录了年轻人和老年人的脑电图（EEG）。在运动刺激和颜色刺激的WM编码过程中，老年人的选择负性（SN）和α带活动（注意分配的测量指标）存在延迟，SN的延迟和大小预测了随后的识别表现。此外，年龄相关的N1潜伏期延迟特别发生在编码颜色刺激时。这些结果表明，在选择性信息编码的速度上，普遍的基于特征的和特定特征的缺陷都是导致老年人WM表现缺陷的原因。
Declines in neural processing speed have been proposed to underlie a broad range of cognitive deficits in older adults. However, the impact of delays in neural processing during stimulus encoding on working memory (WM) performance is not well understood. In the current study, we assessed the influence of aging on the relationship between neural measures of processing speed and WM performance during a selective delayed-recognition task for color and motion stimuli, while electroencephalography (EEG) was recorded in young and older adults. A latency delay was observed for the selection negativity (SN) and alpha band activity (measures of attentional allocation) in older adults during WM encoding of both motion and color stimuli, with the latency and magnitude of the SN predicting subsequent recognition performance. Furthermore, an age-related delay in the N1 latency occurred specifically during the encoding of color stimuli. These results suggest that the presence of both generalized feature-based and feature-specific deficits in the speed of selective encoding of information contributes to WM performance deficits in older adults.