Ontogeny of somatostatin in the human gastro-intestinal tract, endocrine pancreas and hypothalamus.
Ontogeny of somatostatin in the human gastro-intestinal tract, endocrine pancreas and hypothalamus.
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生长抑素在人类胃肠道、内分泌胰腺和下丘脑中的个体发育。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
M. Dubois
中科院分区：
文献类型：
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作者：
J. Chayvialle;C. Paulin;P. Dubois;F. Descos;M. Dubois
本文用免疫细胞化学和放射免疫法对6--32周人胎胰腺、胃肠道和下丘脑生长抑素的出现、时间和分布进行了比较研究。两种方法均在包括结肠在内的所有节段中检测到生长抑素。第一个细胞被观察到，并且生长抑素在胰腺、十二指肠和肠中在8周时以可测量的量存在，而在胃窦和结肠中在12周时、在胃底中在14周时和在下丘脑中在16周时检测到肽。随后，最大的细胞群位于胰腺中，其中肽浓度和年龄呈正相关（P <0.01，r = 64）。从15到21周龄，胰腺中的平均生长抑素浓度（12.4 +/- 1.84 ng/mg）明显高于下丘脑（0.05 +/- 0.02 ng/mg）或肠道的任何部分，其值范围为0.36 +/- 0.06（胃底）至4.74 +/- 0.83 ng/mg（十二指肠）。生长抑素的早期出现时间和其在胰腺中的优先位置的特定分布表明，该肽可能对胎儿消化道的发育起主要作用，并且可能参与其他内分泌分泌的调节，特别是在胰腺中。
The appearance, time and distribution of somatostatin in the pancreas, gastro-intestinal tract and hypothalamus were studied comparatively in human foetuses aged 6--32 weeks, by immuno-cytochemistry and radioimmunoassay. Somatostatin was detected by both methods in all segments including the colon. The first cells were observed, and somatostatin was present in measurable amounts at 8 weeks in pancreas, duodenum and intestine, while the peptide was detected at 12 weeks in antrum and colon, at 14 weeks in fundus, and at 16 weeks in hypothalamus. Subsequently, the largest cell population was located in the pancreas, where peptide concentration and age were positively correlated (P less than 0.01, r = 64). From 15 to 21 weeks of age, the mean somatostatin concentration in pancreas (12.4 +/- 1.84 ng/mg) was clearly higher than in hypothalamus (0.05 +/- 0.02 ng/mg) or in any segment of the gut, where values ranged from 0.36 +/- 0.06 (fundus) to 4.74 +/- 0.83 ng/mg (duodenum). The early appearance time of somatostatin, and its specific distribution with preferential location in the pancreas, suggest that the peptide may play a major role for the development of the foetal digestive tract, and that it may be involved in the regulation of other endocrine secretions, especially in the pancreas.