Attractive natural products with strained cyclopropane and/or cyclobutane ring systems
Attractive natural products with strained cyclopropane and/or cyclobutane ring systems
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具有应变环丙烷和/或环丁烷环系统的有吸引力的天然产物
DOI：
10.1007/s11426-016-0233-1
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发表时间：
2016-09-01
影响因子：
9.6
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Fan, Yao-Yue;Gao, Xin-Hua;Yue, Jian-Min
张力环丙烷和/或环丁烷亚基出现在许多复杂的天然产物中，包括萜类、类固醇和生物碱。具有环丙烷和/或环丁烷基序的天然产物不仅具有迷人的结构，而且具有多种生物活性，如细胞毒性、抗hiv、抗菌、抗病毒和免疫抑制作用。本文综述了大量结构独特的环丙烷和/或环丁烷基序天然产物，综述了它们的结构特征、分布、生物活性以及生物遗传学方面的考虑。
The strained cyclopropane and/or cyclobutane subunits occurred in many complex natural products including terpenoids, steroids and alkaloids. Natural products with cyclopropane and/or cyclobutane motifs not only furnished fascinating structures, but also exhibited versatile biological activities, such as cytotoxic, anti-HIV, antimicrobial, antiviral, and immunosuppressive effects. This review covered a large array of structurally unique natural products with strained cyclopropane and/or cyclobutane motifs and summarized their structural features, distributions, biological activities, as well as biogenetic considerations.