Identifying Cellular and Molecular Mechanisms for Magnetosensation.

Identifying Cellular and Molecular Mechanisms for Magnetosensation.
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DOI:
10.1146/annurev-neuro-072116-031312
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发表时间:
2017-07-25
影响因子:
13.9
通讯作者:
Pierce JT
Pierce JT
中科院分区:
医学1区
文献类型:
--
作者:
Clites BL;Pierce JT

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从蠕虫和昆虫到鸟类和乌龟,各种动物利用地球磁场作为线索进行令人印象深刻的旅程。尽管在过去三十年中已经阐明了感知机械和化学信号的主要细胞和分子机制,但动物用来感知磁场的机制在很大程度上仍然是个谜。在这里,我们调查了寻找对动物行为重要的磁感神经元和磁敏分子的进展。重点是昆虫和鸟类的磁感应,以及线虫秀丽隐杆线虫中的磁感应神经元对 AFD。我们还回顾了用于定义动物磁感受器的传统标准,并建议如何将用于识别其他感觉方式的受体的方法适用于磁感受器。最后,我们讨论了识别动物中难以捉摸的磁感受器的未充分利用的新方法的前景。
Diverse animals ranging from worms and insects to birds and turtles perf orm impressive journeys using the magnetic field of the earth as a cue. Although major cellular and molecular mechanisms for sensing mechanical and chemical cues have been elucidated over the past three decades, the mechanisms that animals use to sense magnetic fields remain largely mysterious. Here we survey progress on the search for magnetosensory neurons and magnetosensitive molecules important for animal behaviors. Emphasis is placed on magnetosensation in insects and birds, as well as on the magnetosensitive neuron pair AFD in the nematode Caenorhabditis elegans. We also review conventional criteria used to define animal magnetoreceptors and suggest how approaches used to identify receptors for other sensory modalities may be adapted for magnetoreceptors. Finally, we discuss prospects for under-utilized and novel approaches to identify the elusive magnetoreceptors in animals.
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