Efficacy of excimer light therapy (308 nm) for palmoplantar pustulosis with the induction of circulating regulatory T cells
Efficacy of excimer light therapy (308 nm) for palmoplantar pustulosis with the induction of circulating regulatory T cells
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DOI：
10.1111/j.1600-0625.2011.01316.x
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发表时间：
2011-09-01
影响因子：
3.6
通讯作者：
Morita, Akimichi
中科院分区：
文献类型：
--
作者：
Furuhashi, Takuya;Torii, Kan;Morita, Akimichi
在这项开放式研究中，我们研究了准分子光(308 Nm)和滤光片切断297 nm以下波长的治疗掌跖脓疱病(PPP)的疗效。20名PPP患者被招募，每周治疗一次，共30次。根据掌底脓疱病面积和严重程度指数(PPPASI)评分，每10个疗程评估患者的反应。同时检测PPP患者外周血中Th17细胞和调节性T细胞(Treg)的水平。平均PPPASI评分基线为19.5，10个治疗组为13.2，20个治疗组为10.9，30个治疗组为9.5。准分子治疗后Th17水平与基线水平无显著差异。相比之下，准分子治疗后的Treg水平显著高于基线水平。
In this open-label study, we investigated the efficacy of excimer light (308 nm) with a filter to cut off wavelengths below 297 nm for the treatment of palmoplantar pustulosis (PPP). Twenty patients with PPP were recruited and treated once a week for a total of 30 sessions. Patient response was assessed every 10 sessions based on the Palmoplantar Pustulosis Area and Severity Index (PPPASI) score. Levels of Th17 cells and regulatory T cells (Treg) in the peripheral blood in patients with PPP were also evaluated. Mean PPPASI score was 19.5 at baseline, 13.2 at 10 treatments, 10.9 at 20 treatments and 9.5 at 30 treatments. Th17 levels after excimer therapy were not significantly different from those at baseline. In contrast, Treg levels after excimer therapy were significantly higher than those at baseline.