Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET.
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET.
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DOI：
10.1016/j.febslet.2011.07.020
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发表时间：
2011-09-02
期刊：
影响因子：
3.5
通讯作者：
Iqbal K
中科院分区：
文献类型：
--
作者：
Arnaud L;Chen S;Liu F;Li B;Khatoon S;Grundke-Iqbal I;Iqbal K
蛋白磷酸酶2a （PP2A）活性在阿尔茨海默病脑中受损，受两种内源性抑制剂调节，其中一种是I2PP2A，一种277个氨基酸的长蛋白，也被称为SET。在这里，我们报道了I2PP2A的氨基端片段（I2NTF; aa 1-175）和羧基端片段（I2CTF; aa 176-277）通过与PP2A的催化亚基PP2Ac结合来抑制PP2A，并导致tau的过度磷酸化。I2CTF的c端酸性区和I2NTF的Val 92对它们与PP2Ac的关联和磷酸酶活性的抑制至关重要。
Protein phosphatase-2A (PP2A) activity, which is compromised in Alzheimer disease brain, is regulated by two endogenous inhibitors, one of them being I2PP2A, a 277 amino acid long protein also known as SET. Here we report that both the amino terminal fragment (I2NTF; aa 1–175) and the carboxy terminal fragment (I2CTF; aa 176–277) of I2PP2A inhibit PP2A by binding to its catalytic subunit PP2Ac and cause hyperphosphorylation of tau. The C-terminal acidic region in I2CTF and Val 92 in I2NTF are essential for their association with PP2Ac and inhibition of the phosphatase activity.
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影响因子：
4.2
作者：
Liu, Gong-Ping;Zhang, Yao;Wang, Jian-Zhi
通讯作者：
Wang, Jian-Zhi
影响因子：
5.6
作者：
Miyaji-Yamaguchi, M;Okuwaki, M;Nagata, K
通讯作者：
Nagata, K
影响因子：
16
作者：
Liu, Zhixue;Jang, Sung-Wuk;Ye, Keqiang
通讯作者：
Ye, Keqiang
影响因子：
5.3
作者：
Liu R;Zhou XW;Tanila H;Bjorkdahl C;Wang JZ;Guan ZZ;Cao Y;Gustafsson JA;Winblad B;Pei JJ
通讯作者：
Pei JJ
影响因子：
64.5
作者：
Seo, SB;McNamara, P;Chakravarti, D
通讯作者：
Chakravarti, D