Antibodies to serine proteases in the antiphospholipid syndrome.
Antibodies to serine proteases in the antiphospholipid syndrome.
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DOI：
10.1007/s11926-009-0072-7
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发表时间：
2010-02-01
影响因子：
5
通讯作者：
Giles, Ian
中科院分区：
文献类型：
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作者：
Chen, Pojen P;Giles, Ian
一般认为抗磷脂综合征（APS）中抗磷脂抗体（aPL）的主要自身抗原是β（2）-糖蛋白I（β（2）GPI）。然而，最近的一项研究表明，一些aPL与β（2）GPI上的某些构象表位结合，这些表位由参与止血和纤维蛋白溶解的几种丝氨酸蛋白酶的同源酶结构域共享。重要的是，一些丝氨酸蛋白酶反应性aPL相应地阻碍抗凝调节和血块的解决。这些结果扩展了aPL与其他凝血因子结合的几个早期发现，并就促进血栓形成的结合特异性和相关功能特性提供了有关某些aPL的新观点。此外，最近对一组人IgG单克隆aPL的免疫学和病理学研究表明，与凝血酶强结合的aPL促进体内静脉血栓形成和白细胞粘附，表明aPL与凝血酶的反应性可能是aPL致病潜力的良好预测因子。
It is generally accepted that the major autoantigen for antiphospholipid antibodies (aPL) in the antiphospholipid syndrome (APS) is beta(2)-glycoprotein I (beta(2)GPI). However, a recent study has revealed that some aPL bind to certain conformational epitope(s) on beta(2)GPI shared by the homologous enzymatic domains of several serine proteases involved in hemostasis and fibrinolysis. Importantly, some serine protease-reactive aPL correspondingly hinder anticoagulant regulation and resolution of clots. These results extend several early findings of aPL binding to other coagulation factors and provide a new perspective about some aPL in terms of binding specificities and related functional properties in promoting thrombosis. Moreover, a recent immunological and pathological study of a panel of human IgG monoclonal aPL showed that aPL with strong binding to thrombin promote in vivo venous thrombosis and leukocyte adherence, suggesting that aPL reactivity with thrombin may be a good predictor for pathogenic potentials of aPL.