Preclinical models to investigate retinal ischemia: advances and drawbacks.
Preclinical models to investigate retinal ischemia: advances and drawbacks.
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DOI：
10.3389/fneur.2012.00075
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发表时间：
2012
影响因子：
3.4
通讯作者：
Anand A
中科院分区：
文献类型：
--
作者：
Minhas G;Morishita R;Anand A
视网膜缺血是世界范围内致盲的主要原因。它与各种疾病有关，如糖尿病视网膜病变、青光眼、视神经病变、中风和其他视网膜病变。视网膜缺血是由于视网膜缺乏适当的血液供应而发生的临床病症。由于视网膜具有更高的代谢需求，血液供应的任何障碍都可能导致氧气供应减少，从而导致视网膜缺血。视网膜缺血的病理学仍不清楚。为了更好地了解视网膜缺血的病理生理学，动物模型的作用是必不可少的。视网膜缺血的标准治疗护理潜力有限。干细胞移植提供神经保护并补充受损细胞是治疗视网膜缺血的新兴治疗方法。在这篇综述中，我们提供了一个概述视网膜缺血的主要动物模型，沿着与当前和临床前的治疗方法。
Retinal ischemia is a major cause of blindness worldwide. It is associated with various disorders such as diabetic retinopathy, glaucoma, optic neuropathies, stroke, and other retinopathies. Retinal ischemia is a clinical condition that occurs due to lack of appropriate supply of blood to the retina. As the retina has a higher metabolic demand, any hindrance in the blood supply to it can lead to decreased supply of oxygen, thus causing retinal ischemia. The pathology of retinal ischemia is still not clearly known. To get a better insight into the pathophysiology of retinal ischemia, the role of animal models is indispensable. The standard treatment care for retinal ischemia has limited potential. Transplantation of stem cells provide neuroprotection and to replenish damaged cells is an emerging therapeutic approach to treat retinal ischemia. In this review we provide an overview of major animal models of retinal ischemia along with the current and preclinical treatments in use.