Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells.
Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells.
复制标题
经历抗原的 CD8 T 细胞中细胞命运决定的转录控制。
DOI：
10.1101/cshperspect.a037945
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发表时间：
2022
影响因子：
7.2
通讯作者：
Pipkin,MatthewE
中科院分区：
文献类型：
--
作者：
Tsuda,Shanel;Pipkin,MatthewE
对细胞内感染的强大免疫力是由抗原特异性的幼稚CD8 T细胞介导的，这些细胞被激活并分化为表型和功能多样化的效应细胞亚群，其中一些是终末分化的，另一些是产生记忆细胞的，提供长期保护。这个发育系统是一个杰出的模型，用它来阐明染色质结构的调节和转录控制如何建立控制细胞命运的基因表达程序，从中获得的见解可能有助于设计免疫治疗方法，以设计对感染和肿瘤的持久免疫。一个描述原始CD8T细胞如何发育成记忆细胞的统一框架仍然很出色。我们提出了一个模型，该模型结合了一个共同的早期线性路径，然后是逐渐失去相互转换能力的分歧路径，并讨论了支持这些概念的经典和当代观察，重点是从转录控制和染色质调节的见解。
Robust immunity to intracellular infections is mediated by antigen-specific naive CD8 T cells that become activated and differentiate into phenotypically and functionally diverse subsets of effector cells, some of which terminally differentiate and others that give rise to memory cells that provide long-lived protection. This developmental system is an outstanding model with which to elucidate how regulation of chromatin structure and transcriptional control establish gene expression programs that govern cell fate determination, insights from which are likely to be useful for informing the design of immunotherapeutic approaches to engineer durable immunity to infections and tumors. A unifying framework that describes how naive CD8 T cells develop into memory cells is still outstanding. We propose a model that incorporates a common early linear path followed by divergent paths that slowly lose capacity to interconvert and discuss classical and contemporary observations that support these notions, focusing on insights from transcriptional control and chromatin regulation.