Metabolic control of elastic properties of the inner mitochondrial membrane
Metabolic control of elastic properties of the inner mitochondrial membrane
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DOI：
10.1021/jp0638181
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发表时间：
2006-11-16
影响因子：
3.3
通讯作者：
Chvanov, Michael
中科院分区：
文献类型：
--
作者：
Chvanov, Michael
给出了线粒体膜形状重排的一种可能的物理机制。该分析研究表明，线粒体膜内的高跨膜电位对膜的侧向张力、弯曲刚度常数和高斯曲率弹性模量产生了特定的、实质性的和动态的电化学贡献。线粒体代谢的变化会显著影响这些弹性参数的大小，但并不一定影响质子动力的大小。代谢驱动的线粒体内膜力学特性的变化可以促进膜在其主要几何形状之间的重塑，并在氧化磷酸化的控制中起到负反馈作用。
A possible physical mechanism for inner mitochondrial membrane shape rearrangements is given. This analytical study shows that high transmembrane potential at the inner mitochondrial membrane brings about specific, substantial, and dynamic electrochemical contributions to lateral tension, bending rigidity constant, and elastic modulus of Gaussian curvature of the membrane. Changes in mitochondrial metabolism dramatically affect the magnitude of these elastic parameters but not necessarily that of proton-motive force. Metabolic-driven variation of mechanical properties of the inner mitochondrial membrane can promote the membrane remodeling between its principal geometric shapes and serve as a negative feedback in control of the oxidative phosphorylation.