FAST ALGORITHM FOR PEPTIDE SEQUENCING BY MASS-SPECTROSCOPY
FAST ALGORITHM FOR PEPTIDE SEQUENCING BY MASS-SPECTROSCOPY
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DOI：
10.1002/bms.1200190607
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发表时间：
1990-06-01
期刊：
影响因子：
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通讯作者：
BARTELS, C
中科院分区：
文献类型：
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作者：
BARTELS, C
提出了一种快速原子轰击串联质谱多肽序列自动测定的算法。基于图论的考虑，它找到了最可能的序列，即使氨基酸组成是未知的，通过评分质量差异。当计算时间增加小于氨基酸数目的平方时，该算法是快速的。如果峰缺失，则提出两个或三个氨基酸对来解释差距。
An automatic algorithm for sequencing polypeptides from fast atom bombardment tandem mass spectra is presented. Based on graph theory considerations it finds the most probable sequences, even if the amino acid composition is unknown, by scoring mass differences. The algorithm is fast as the computing time increases by less than the square of the number of amino acids. Pairs of two or three amino acids are proposed to explain the gap if peaks are missing.