Protein phosphorylation and signal transduction.
Protein phosphorylation and signal transduction.
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DOI：
10.1007/978-1-4613-0343-5_5
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发表时间：
1996
影响因子：
--
通讯作者：
Sailen Barik
中科院分区：
文献类型：
--
作者：
Sailen Barik
细胞的表型和行为，就像它所在的生物体的表型和行为一样，不断受到各种外部信号的影响，这些信号最终决定了细胞趋化、增殖、分化甚至死亡（细胞凋亡）等明显不同的现象。相应的细胞外信号也同样不同，例如，营养流、激素、肽生长因子、干扰素和其他细胞因子以及抗原。术语”信号转导”是指给定信号的获取和随后的传递。与电子数据处理操作类似，活细胞中的信号转导在概念上可以分为以下基本步骤：接收信号;将信号转换为细胞的大分子语言;通过一系列相互作用的换能器放大和传导主要信号，有时随后抑制信号以恢复预激发状态;最后执行。一般来说，该途径从细胞表面受体开始，在细胞核中以调节基因转录的蛋白质结束。在这两者之间，
The phenotype and behavior of a cell, just as those of the organism in which it resides, are constantly influenced by a variety of external signals that eventually determine such apparently diverse phenomena as cellular taxis, proliferation, differentiation, and even death (apoptosis). The corresponding extracellular signals are equally varied, eg, nutrient flux, hormones, peptide growth factors, interferons and other cytokines, and antigens. The term" signal transduction" refers to the acquisition and subsequent transmission of a given signal. In analogy to electronic data-processing operations, signal transduction in living cells can be conceptually dissected into the following basic steps: receiving of the signal; conversion of the signal to the macromolecular language of the cell; amplification and conduction of the primary signal through a series of interactive transducers, sometimes followed by dampening of the signal to restore the preexcited state; and finally execution. The pathway, in general, begins with cell surface receptors and ends in the cell nucleus with proteins that regulate gene transcription. In between, each protein component of the pathway integrates