Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis
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DOI：
10.1038/s41598-020-69078-9
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发表时间：
2020-07-21
影响因子：
4.6
通讯作者：
Nansseu, Jobert Richie
中科院分区：
文献类型：
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作者：
Bigna, Jean Joel;Tochie, Joel Noutakdie;Nansseu, Jobert Richie
为孕妇提供有效的医疗保健需要关于全球、区域和国家各级妊娠期弓形虫病患病率的准确数据。在这篇包含荟萃分析和建模分析的系统综述中，我们检索了 PubMed、EMBASE、Web of Knowledge、Global Index Medicus 和 Africa Journal Online，以确定报告了足够数据来计算截至 2018 年 12 月 31 日孕妇中弓形虫免疫球蛋白 (Ig) M 或 G 血清阳性率估计值的研究，且没有任何语言限制。全球和区域估计是使用随机效应荟萃分析完成的。我们纳入了 250 项研究，涉及 723,655 名孕妇。全球 IgM 血清阳性率为 1.9%（95%CI：1.7-2.3）。在区域层面，东地中海的 IgM 血清阳性率最高（4.1%，95%CI：2.8-5.5），美洲最低（1.1%，0.8-1.4），WHO 各区域之间存在统计显着差异（p
Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7-2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8-5.5) and The Americas, the lowest (1.1%, 0.8-1.4), with a statistically significant difference between WHO regions (p