The Effect of Moderate to Heavy Alcohol Consumption on Neuropsychological Performance as Measured by the Repeatable Battery for the Assessment of Neuropsychological Status
The Effect of Moderate to Heavy Alcohol Consumption on Neuropsychological Performance as Measured by the Repeatable Battery for the Assessment of Neuropsychological Status
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DOI：
10.1111/j.1530-0277.2009.01108.x
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发表时间：
2010-03-01
影响因子：
3.2
通讯作者：
Harper, Clive
中科院分区：
文献类型：
--
作者：
Green, Alisa;Garrick, Therese;Harper, Clive
背景：过量饮酒与大脑结构和功能的损害以及认知和行为的损害有关。用于评估酗酒者认知表现的传统测试组合是广泛和昂贵的，限制了它们在各种临床和研究环境中的使用。用于评估神经心理状态的可重复成套测验（RBANS）是一种相对较新的工具，试图克服其中的一些局限性。到目前为止，还没有研究过中度到重度饮酒对RBANS表现的个体影响。本研究的主要目的是探索和量化控制和饮酒者之间的RBANS的表现差异，并检查年龄，性别和酒精使用模式对测试performance.Methods的影响：数据来自一个子集的“用我们的大脑”（UoB）捐助者（n = 28）仍然积极饮酒，并符合标准的中度到重度饮酒（每天30至80 g乙醇）（哈珀，1988）和28个匹配对照（年龄、文化程度、病前智商）进行比较。酒精组的参与者在视觉空间和即时记忆指数以及RBANS总分方面的表现低于健康对照组，p < 0.001，并且RBANS评分从估计的横截面发病前水平下降更大。在过去12个月内饮酒与语言指数p < 0.03和语义流畅性子测试（p < 0.03）呈正相关。年龄与故事记忆（p < 0.02）、编码（p < 0.001）、列表再认（p <0.01）、故事回忆（p < 0.03）和图形回忆（p < 0.02）呈负相关。结论：我们的研究结果表明，RBANS能够检测和表征健康对照组和中度至重度活跃酒精使用者之间的言语流畅性、视觉空间技能、陈述性记忆成分和心理速度的差异。执行功能，通常受酒精中毒的影响，不包括在RBANS，需要评估与其他措施。
Background:Excessive alcohol use is associated with damage to the structure and function of the brain and impairment of cognition and behavior. Traditional test batteries used to assess cognitive performance in alcoholics are extensive and costly, limiting their use across various clinical and research settings. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a relatively new instrument that attempts to overcome some of these limitations. As yet the individual effect of moderate to heavy alcohol consumption on RBANS performance has not been examined. The primary aim of this study was to explore and quantify differences in performance between controls and drinkers on the RBANS and to examine the influence of age, gender, and alcohol use patterns on test performance.Methods:Data from a subset of "Using Our Brains" (UoB) donors (n = 28) still actively drinking and meeting criteria for moderate to heavy alcohol use (30 to 80 g of ethanol per day) (Harper, 1988) and 28 matched controls (age, education, and premorbid Intelligence Quotient) were compared.Results:Participants in the alcohol group performed below the healthy control group on the visuospatial and immediate memory index, and also on the RBANS total score p < 0.001 and showed a greater decline in RBANS scores from estimated cross-sectional premorbid levels. There was a positive association between alcohol ingestion in the preceding 12 months and the language index p < 0.03 and the semantic fluency subtest (p < 0.03). Age was negatively associated with story memory (p < 0.02), coding (p < 0.001), list recognition (p < 0.01), story recall (p < 0.03), and figure recall (p < 0.02).Conclusion:Our results suggest that the RBANS is able to detect and characterize differences in verbal fluency, visuospatial skills, components of declarative memory, and psychomotor speed between healthy controls and moderate to heavy active alcohol users. Executive functions, commonly affected by alcoholism and not included in the RBANS, require assessment with additional measures.