EARLY PHARMACOKINETICS AND CLINICAL EFFECTS OF ORAL D-AMPHETAMINE IN NORMAL SUBJECTS
EARLY PHARMACOKINETICS AND CLINICAL EFFECTS OF ORAL D-AMPHETAMINE IN NORMAL SUBJECTS
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DOI：
10.1016/0006-3223(87)90070-9
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发表时间：
1987-11-01
影响因子：
10.6
通讯作者：
COOPER, T
中科院分区：
文献类型：
--
作者：
ANGRIST, B;CORWIN, J;COOPER, T
7名正常受试者接受0.25 mg/kg D-苯丙胺口服，均在过夜禁食后和标准早餐后。血浆水平，主观和心血管影响，和神经元额定激活进行评估，每小时5小时。食物不影响安非他明水平。血浆水平在2-3小时达到峰值。最大心血管效应一般发生在1小时，而最大行为和主观效应发生在2小时。主观和行为效应此后下降，尽管大量安非他明水平。另一组8名受试者口服0.5 mg/kg D-苯丙胺。血浆水平，主观和心血管效应，和激活评级进行评估，每小时4小时。最大血浆水平约为第一组的两倍。在这种情况下，血浆水平在3-4小时达到峰值;尽管血浆水平稳定或升高，但血压以及主观和行为效应均在2-3小时达到最大值，并在4小时下降。
Seven normal subjects received 0.25 mg/kg D-amphetamine orally, both after an overnight fast and again after a standard breakfast. Plasma levels, subjective and cardiovascular effects, and observer-rated activation were assessed hourly for 5 hr. Food did not affect amphetamine levels. Plasma levels peaked at 2-3 hr. Maximum cardiovascular effects generally occurred at 1 hr, whereas maximum behavioral and subjective effects occurred at 2 hr. Subjective and behavioral effects declined thereafter, in spite of substantial amphetamine levels. A separate group of 8 subjects received 0.5 mg/kg D-amphetamine orally. Plasma levels, subjective and cardiovascular effects, and activation ratings were assessed hourly for 4 hr. Maximum plasma levels were approximately twice those seen in the first group. In this case, plasma levels peaked at 3-4 hr; blood pressure and subjective and behavioral effects were all maximal at 2-3 hr and were declining by 4 hr, in spite of stable or rising plasma levels.