Reduced attenuation of bone resorption after oral glucose in type 2 diabetes
Reduced attenuation of bone resorption after oral glucose in type 2 diabetes
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DOI：
10.1111/j.1365-2265.2007.03159.x
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Ongphiphadhanakul, Boonsong
中科院分区：
文献类型：
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作者：
Chailurkit, La-or;Chanprasertyothin, Suwannee;Ongphiphadhanakul, Boonsong
目的探讨口服葡萄糖对不同糖耐量受试者骨吸收和骨保护素（OPG）的影响。方法采用横断面研究方法，选取163名绝经后妇女，年龄50-88岁，无糖尿病、空腹血糖受损（IFG）或糖耐量受损（IGT）病史。所有受试者均接受75 g口服葡萄糖耐量试验（OGTT），然后根据美国糖尿病协会（ADA）标准将其分为正常葡萄糖耐量（NGT）、IFG、IGT或糖尿病。测量血糖、血清胰岛素、I型胶原C末端肽（CTX-I）和OPG。结果从NGT、IFG/IGT到糖尿病，空腹胰岛素水平逐渐升高。校正年龄和体重指数（BMI）后，不同糖耐量的空腹CTX-I和OPG水平无显著差异。口服葡萄糖后，除糖尿病患者血清OPG外，其他血清CTX-I和OPG均显著降低（P < 0.001）。此外，糖尿病患者血清CTX-I和OPG较基线的变化百分比显著低于NGT患者（糖尿病患者分别为-40.9%和0.6%，NGT患者分别为-50.2%和10.6%，P <0.01）。2型糖尿病患者的血糖水平明显下降。
Objective To investigate the effect of oral glucose on bone resorption and osteoprotegerin (OPG) in subjects with varying degrees of glucose tolerance.Design and Patients In a cross-sectional study, 163 postmenopausal women aged 50-88 years without previous history of diabetes, impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) were recruited. All subjects underwent a 75-g oral glucose tolerance test (OGTT) and were then classified as having normal glucose tolerance (NGT), IFG, IGT or diabetes according to American Diabetes Association (ADA) criteria.Measurements Plasma glucose, serum insulin, C-terminal telopeptide of type I collagen (CTX-I) and OPG were measured.Results Fasting insulin levels increased progressively from subjects with NGT, IFG/IGT to diabetes. After adjusted for age and body mass index (BMI), there was no significant difference in fasting CTX-I and OPG levels across the various degrees of glucose tolerance. After oral glucose, there was a significant decrease in serum CTX-I and OPG (P < 0.001) except for serum OPG in diabetic subjects. In addition, the percentages of change from baseline for both serum CTX-I and OPG were significantly less in diabetic subjects when compared to those in NGT subjects (-40.9% and 0.6% for diabetes and -50.2% and -10.6% for NGT, respectively).Conclusions Oral glucose intake causes suppression of serum CTX-I and OPG in postmenopausal women. The effect is attenuated in women with type 2 diabetes.