Ganglioside complexes as new target antigens in Guillain-Barre syndrome
Ganglioside complexes as new target antigens in Guillain-Barre syndrome
复制标题
DOI：
10.1002/ana.20222
复制
发表时间：
2004-10-01
影响因子：
11.2
通讯作者：
Kusunoki, S
中科院分区：
文献类型：
--
作者：
Kaida, K;Morita, D;Kusunoki, S
应用酶联免疫吸附试验和薄层层析免疫染色方法，在100例格林-巴利综合征(GBS)患者血清中检测到8例神经节苷脂GD1a/GD1b抗体。这些血清对GD1a/GM1、GD1b/GT1b和GM1/GT1b等神经节苷脂复合体也有抗体活性，但对各分离抗原几乎没有反应。细胞膜上神经节苷脂复合体的簇状表位可能是这种抗体的靶点，抗体与神经节苷脂复合体之间的相互作用可能会导致神经病变。
Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain-Barre syndrome (GBS) by the use of enzyme-linked immunosorbent assay and thin-layer chromatogram immunostaining. Those sera also had antibody activities to such ganglioside complexes as GD1a/GM1, GD1b/GT1b, and GM1/GT1b but had little or no reactivity to the each isolated antigen. Clustered epitopes of the ganglioside complex in the plasma membrane may be targeted by such an antibody, and interaction between the antibody and ganglioside complex may induce the neuropathy.