Successful Treatment by Fibrin Glue Sealant for Pneumothorax with Chronic GVHD Resistant to Autologous Blood Patch Pleurodesis
Successful Treatment by Fibrin Glue Sealant for Pneumothorax with Chronic GVHD Resistant to Autologous Blood Patch Pleurodesis
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DOI：
10.2169/internalmedicine.51.7355
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发表时间：
2012-01-01
影响因子：
1.2
通讯作者：
Kato, Junji
中科院分区：
文献类型：
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作者：
Iyama, Satoshi;Sato, Tsutomu;Kato, Junji
干细胞移植后与慢性移植物抗宿主病（cGVHD）相关的气胸是一种罕见的并发症。自体血液已成功用于胸膜固定术，其毒性低于化学制剂。然而，当气胸对胸膜固定术有抵抗力时，没有其他手术更有效和保守。在此，我们描述一例骨髓增生异常综合征并发 cGVHD 相关气胸的病例。他的气胸对使用自体血液的胸膜固定术有抵抗力，并用纤维蛋白胶密封剂成功治疗。根据我们有限的经验，我们相信当这种方法用于治疗伴有cGVHD的持续性气胸时可以获得最大的成功。
Pneumothorax associated with chronic graft-versus-host disease (cGVHD) after stem cell transplantation is a rare complication. Autologous blood has been used successfully for pleurodesis, which was less toxic than chemical agents. However, when pneumothorax is resistant to pleurodesis, no other procedure is more effective and conservative. Here, we describe a case of myelodysplastic syndromes complicated with cGVHD-related pneumothorax. His pneumothorax has been resistant to pleurodesis using autologous blood and was treated successfully with fibrin glue sealant. In our limited experience, we believe the best success could be achieved when this method is used to treat persistent pneumothorax with cGVHD.