Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R.
Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R.
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DOI：
10.1099/mic.0.2006/003657-0
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发表时间：
2007-04
期刊：
影响因子：
1.5
通讯作者：
H. Yukawa;Crispinus A. Omumasaba;H. Nonaka;P. Kós;N. Okai;N. Suzuki;Masako Suda;Y. Tsuge;J. Watanabe;Yoko Ikeda;A. Vertès;M. Inui
中科院分区：
文献类型：
--
作者：
H. Yukawa;Crispinus A. Omumasaba;H. Nonaka;P. Kós;N. Okai;N. Suzuki;Masako Suda;Y. Tsuge;J. Watanabe;Yoko Ikeda;A. Vertès;M. Inui
测定谷氨酸棒杆菌菌株R的全基因组序列以允许其与其它棒杆菌的比较分析。棒状杆菌的生物学进行了探讨，通过完善的基因子集的定义，构成棒状杆菌的核心，以及那些特有的sacetotic和致病性的生态位。此外，棒状杆菌σ因子的相对稀缺性和它们的双组分系统机制的可塑性反映了它们相对严格的营养需求和减少的膜相关和分泌的蛋白质。棒状杆菌、分枝杆菌和诺卡氏菌之间关键基因和途径的保守性验证了C.谷氨酸研究的基本过程是保守的缓慢生长的分枝杆菌，包括发病机制相关的机制。发现了39个新基因。先前在其它棒状杆菌中未报道的谷氨酸R的突变支持了对另外的棒状杆菌基因组进行测序以更好地定义棒状杆菌泛基因组并鉴定这些生物体中先前未检测到的代谢途径的基本原理。
The complete genome sequence of Corynebacterium glutamicum strain R was determined to allow its comparative analysis with other corynebacteria. The biology of corynebacteria was explored by refining the definition of the subset of genes that constitutes the corynebacterial core as well as those characteristic of saprophytic and pathogenic ecological niches. In addition, the relative scarcity of corynebacterial sigma factors and the plasticity of their two-component system machinery reflect their relatively exacting nutritional requirements and reduced membrane-associated and secreted proteins. The conservation of key genes and pathways between corynebacteria, mycobacteria and Nocardia validates the use of C. glutamicum to study fundamental processes that are conserved in slow-growing mycobacteria, including pathogenesis-associated mechanisms. The discovery of 39 novel genes in C. glutamicum R that have not been previously reported in other corynebacteria supports the rationale for sequencing additional corynebacterial genomes to better define the corynebacterial pan-genome and identify previously undetected metabolic pathways in these organisms.