TRANSMISSION RATIO DISTORTION IN MOUSE TERT-HAPLOTYPES IS DUE TO MULTIPLE DISTORTER GENES ACTING ON A RESPONDER LOCUS
TRANSMISSION RATIO DISTORTION IN MOUSE TERT-HAPLOTYPES IS DUE TO MULTIPLE DISTORTER GENES ACTING ON A RESPONDER LOCUS
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DOI：
10.1016/0092-8674(84)90393-3
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发表时间：
1984-01-01
期刊：
影响因子：
64.5
通讯作者：
LYON, MF
中科院分区：
文献类型：
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作者：
LYON, MF
部分t-单倍型的各种组合的雄性小鼠杂合子的传输比提供了证据，支持一个模型的遗传基础的比例失真，涉及2个或更多的失真基因作用于一个响应基因座。在单倍型的中间部分，反应基因座的t型Tcr必须存在并且杂合才能发生畸变。当应答者单独存在时，如在tlow单倍型中，携带它的染色体以低比率（< 50%）传递。畸变基因座的t型在顺式或反式中起相加作用，以提高携带Tcr的染色体的传递。确定的扭曲位点是Tcd-1，在近端部分的单倍型，Tcd-2，远端Tcr，可能Tcd-3，躺在Tcr和Tcd-2之间。在没有Tcr的情况下，失真物正常传输。该系统与果蝇的SD系统进行了比较。
Transmission ratios of male mice heterozygous for various combinations of partial t-haplotypes provide evidence in support of a model for the genetic basis of ratio distortion, involving 2 or more distorter genes acting on a responder locus. The t form of the responder locus, Tcr, in the medial part of the haplotype, must be present and heterozygous for distortion to occur. When the responder alone is present, as in tlow haplotypes, the chromosome carrying it is transmitted in a low ratio (< 50%). The t forms of the distorter loci act additively, in cis or trans, to raise the transmission of whichever chromosome carries Tcr. Identified distorter loci are Tcd-1, in the proximal part of the haplotype, Tcd-2, distal to Tcr, and probably Tcd-3, lying between Tcr and Tcd-2. In the absence of Tcr the distorters are transmitted normally. The system is compared with the SD [segregation distortion] system of Drosophila.