A study on pathogenicity and mosquito transmission success in the rodent malaria parasite Plasmodium chabaudi adami
A study on pathogenicity and mosquito transmission success in the rodent malaria parasite Plasmodium chabaudi adami
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DOI：
10.1016/j.ijpara.2008.07.005
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发表时间：
2009-02-01
影响因子：
4
通讯作者：
Carter, Richard
中科院分区：
文献类型：
--
作者：
Gadsby, Naomi;Lawrence, Richard;Carter, Richard
我们调查了啮齿类动物夏氏疟原虫（Plasmodium chabaudi adami）的两个菌株DS和DK在小鼠血液感染中对蚊子的寄生虫学、致病性（毒力）和感染性。DS的血液感染被认为是高致病性的，在这些感染中的无性寄生虫生长迅速，并没有表现出选择性感染宿主红细胞的证据。与DS相反，DK的血液感染的致病性低得多;无性寄生虫生长缓慢，并表现出中等程度的选择性红细胞的子集，而不是网织红细胞。在DS和DK感染中，在无性寄生虫血症高峰发生之前，对蚊子的感染性最高;通常这与血液中配子体数量最高的时间不一致。CBA小鼠感染致病性DS菌株产生的配子母细胞比致病性较低的DK菌株少。在CBA和C57小鼠中的DS菌株感染对蚊子的感染性也显著低于DK菌株。其他人对相关啮齿类疟疾寄生虫亚种夏氏疟原虫（Plasmodium chabaudi chabaudi）的研究表明，蚊子对小鼠血液感染的感染力在致病性较高（毒性）的寄生虫亚种中往往较高，而在致病性较低的菌株中则较低。这与目前对A c血液感染的调查结果匡威。在小鼠中，这些寄生虫的致病性或毒性更强的菌株（DS）对蚊子的感染性比致病性较低的菌株（DK）显著低得多。(c)2008年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
We investigated the parasitology, pathogenicity (virulence) and infectivity to mosquitoes of blood infections in mice, of two strains, DS and DK, of the rodent malaria parasite Plasmodium chabaudi adami. Blood infections of DS were found to be highly pathogenic; the asexual parasites in these infections were fast-growing and showed no evidence of selectivity in their infection of host erythrocytes. In contrast to DS, blood infections of DK were much less pathogenic; the asexual parasites were slower-growing and showed a moderate degree of selectivity to a subset of erythrocytes which were not reticulocytes. In both DS and DK infections, infectivity to mosquitoes was highest before the peak of asexual parasitaemia had occurred; usually this did not coincide with the time when gametocyte numbers in the blood were highest. Infections with the pathogenic DS strain in CBA mice produced fewer gametocytes than did the less pathogenic DK strain. The DS strain infections in both CBA and C57 mice were also significantly much less infective to mosquitoes than the DK strain. Investigations by others on the related rodent malaria parasite subspecies, Plasmodium chabaudi chabaudi, have indicated that the mosquito infectivity of blood infections in mice tended to be higher in the more pathogenic (virulent) and lower in the less pathogenic strains of this parasite subspecies. This is the converse of the finding of the present investigation of blood infections of A c. adami in mice in which a more pathogenic, or virulent, strain (DS) of these parasites was significantly much less infective to mosquitoes than was a less pathogenic strain (DK). (c) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.