Measurement of functioning hepatocyte mass via [99mTc]galactosyl-neoglycoalbumin.
Measurement of functioning hepatocyte mass via [99mTc]galactosyl-neoglycoalbumin.
复制标题
通过[99mTc]半乳糖基-新糖白蛋白测量功能性肝细胞质量。
DOI：
10.1007/bf01299893
复制
发表时间：
1993
影响因子：
3.1
通讯作者：
Todo,A
中科院分区：
文献类型：
--
作者：
Kudo,M;Vera,DR;Stadalnik,RC;Esquivel,CO;Trudeau,WL;Ikekubo,K;Todo,A
~（99）Tc-半乳糖基-新糖白蛋白（TcNGA）是一种人工合成的肝结合蛋白（HBP）特异性配体，其受体仅存在于肝细胞上，通过肝动力学分析和静脉注射TcNGA后肝清除过程中的血液时间-活性数据，在体测定受体浓度。本研究的目的是评估受体浓度作为功能性肝细胞质量的指标。因此，TcNGA和双注射吲哚菁绿色最大清除率（ICG Rmax）的研究进行了9例肝硬化伴或不伴肝癌。将受体浓度与ICG Rmax进行比较，ICG Rmax是一种经验证的功能性肝细胞质量估计方法。相关系数为0.76（P=0.017）。得出结论，通过功能成像测量的HBP浓度（[HPB]o）是功能性肝细胞质量的量度。这意味着通过使用核医学技术测量个体的受体浓度提供了肝功能质量的客观指标，并支持严格评估[HBP] o的临床疗效的尝试。
Technetium-99m-galactosyl-neoglycoalbumin (TcNGA) is a synthetic radiolabeled ligand specific for hepatic binding protein (HBP), a receptor that resides exclusively on hepatocytes.In vivomeasurement of receptor concentration was obtained via kinetic analysis of liver and blood time-activity data obtained during the hepatic clearance of intravenously administered TcNGA. The purpose of this study was to assess receptor concentration as a measure of the functioning hepatocyte mass. Therefore, TcNGA and dualinjection indocyanine green maximal removal rate (ICG Rmax) studies were performed on nine patients with hepatic cirrhosis associated or not with hepatocellular carcinoma. Receptor concentration was compared with ICG Rmax, which is a validated method for the estimation of the functioning hepatocyte mass. The correlation coefficient was 0.76 (P=0.017). It is concluded that HBP concentration ([HPB]o) as measured by functional imaging is a measure of functioning hepatocyte mass. This implies that measurement of an individual's receptor concentration by using nuclear medicine techniques provides an objective index of hepatic functional mass and supports attempts to rigorously evaluate [HBP]ofor its clinical efficacy.