Long-term survival and prognostic indicators in small (<or=2 cm) pancreatic cancer.
Long-term survival and prognostic indicators in small (<or=2 cm) pancreatic cancer.
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DOI：
10.1159/000161009
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Chari ST
中科院分区：
文献类型：
--
作者：
Pongprasobchai S;Pannala R;Smyrk TC;Bamlet W;Pitchumoni S;Ougolkov A;de Andrade M;Petersen GM;Chari ST
在一项匹配分析中，我们研究了小（≤2 cm）胰腺癌（PaC）与大PaC的临床、组织病理学和生存特征。从Mayo病理数据库中，我们确定了41例连续小PaC患者和94例边缘阴性PaC患者。两名经验丰富的病理学家，不了解生存数据，独立审查肿瘤分期和分化。应用Kaplan-Meier生存分析和Cox比例风险模型进行数据分析。在局限性疾病（I期和II期）患者中，小型和大型PaC的生存率相似，但与类似分期的大型PaC相比，伴有区域淋巴结转移的小型PaC （III期）的生存率明显更好（5年生存率44%对7%，中位生存期58对18个月，p <0.001）。分化良好的小PaC和大PaC的中位生存期相似（76个月vs 74个月，p=ns）。在多变量分析中，肿瘤分化，而不是肿瘤大小，是预测PaC患者生存的唯一独立因素（中度与高分化的风险比[RR]: 2.6, 95%可信区间[CI] 1.5, 4.5，低分化与高分化的风险比[RR]: 5.0, 95% CI 2.4-10.1）。肿瘤分化可能比肿瘤分期更能预测可切除PaC患者的生存。
In a matched analysis, we investigated clinical, histopathological, and survival characteristics of small (≤2 cm) pancreatic cancer (PaC) as compared to large PaC. From the Mayo pathology database, we identified 41 consecutive patients with small PaC and 94 matched controls with margin-negative PaC >2 cm. Two experienced pathologists, who were blinded to survival data, independently reviewed tumor stage and differentiation. Kaplan-Meier survival analysis and Cox proportional hazards models were applied for data analyses. In patients with localized disease (stages I and II), survival was similar in small and large PaC but survival was significantly better in small PaC with regional nodal metastasis (stage III) as compared to similar stage large PaC (5-yr survival 44% vs. 7%, median survival 58 vs.18 months, p <0.001). Well-differentiated small and large PaC had similar median survival (76 vs. 74 months, p=ns). In multivariate analysis, tumor differentiation, not tumor size, was the only independent factor predicting survival in PaC (risk ratio [RR] for moderate vs. well- differentiated: 2.6, 95% confidence interval [CI] 1.5, 4.5, and poorly differentiated vs. well-differentiated: RR 5.0, 95% CI 2.4-10.1). Tumor differentiation may be a better predictor of survival in resectable PaC than tumor stage.
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影响因子：
9
作者：
TSUCHIYA, R;NODA, T;ETO, T
通讯作者：
ETO, T
DOI：
10.1053/ejso.2001.1162
发表时间：
2001-09-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
van Geenen, RCI;van Gulik, TM;Gouma, DJ
通讯作者：
Gouma, DJ
影响因子：
9
作者：
Lim, JE;Chien, MW;Earle, CC
通讯作者：
Earle, CC
影响因子：
9
作者：
NITECKI, SS;SARR, MG;VANHEERDEN, JA
通讯作者：
VANHEERDEN, JA
影响因子：
3
作者：
GEER, RJ;BRENNAN, MF
通讯作者：
BRENNAN, MF