Effects of litter size on sympathetic activity in young adult rats.
Effects of litter size on sympathetic activity in young adult rats.
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产仔数对年轻成年大鼠交感神经活动的影响。
DOI：
10.1152/ajpregu.00139.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Young,JamesB
中科院分区：
文献类型：
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作者：
Young,JamesB
小窝饲养动物会导致体重和体脂的永久增加。为了确定交感肾上腺活动的变化是否与这种影响有关，在出生后的第一天调整产仔数并维持到21天断奶。采用外周组织[3H]去甲肾上腺素（[3H]NE）周转量法测定成年动物交感神经系统（SNS）活性。虽然产仔数对食饲动物的[3H]NE转换没有影响，但在小窝饲养的大鼠中，膳食蔗糖对[3H]NE转换的加速在心脏中完全消除，在肩胛间棕色脂肪组织和肾脏中减弱。小窝饲养的大鼠体重和附睾脂肪垫重较重；然而，饲粮中添加蔗糖的增重对产仔数没有影响。因此，产仔数改变了饮食中SNS的激活，这种影响可能反映了中枢神经系统调节的变化。
Rearing animals in small litters induces a permanent increase in body weight and body fat. To determine whether changes in sympathoadrenal activity contribute to this effect, litter size was adjusted the day after birth and maintained until weaning at 21 days. Sympathetic nervous system (SNS) activity was measured in adult animals using [3H]norepinephrine ([3H]NE) turnover in peripheral tissues. Although litter size was without effect on [3H]NE turnover in chow-fed animals, acceleration of [3H]NE turnover by dietary sucrose was completely abolished in heart and attenuated in interscapular brown adipose tissue and kidney of rats reared in small litters. Body and epididymal fat-pad weights were heavier in rats reared in small litters; however, weight gain in response to dietary enrichment with sucrose did not differ as a function of litter size. Thus litter size alters dietary activation of the SNS, and this effect presumably reflects changes in central nervous system regulation.