THE ROLE OF HUMAN GENETIC MONITORING IN THE WORKPLACE
THE ROLE OF HUMAN GENETIC MONITORING IN THE WORKPLACE
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DOI：
10.1097/00043764-198109000-00011
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发表时间：
1981-01-01
影响因子：
3.2
通讯作者：
DABNEY, BJ
中科院分区：
文献类型：
--
作者：
DABNEY, BJ
本文综述了职业遗传学短期监测的历史和现状。它们是：细胞遗传学、姐妹染色单体交换、体液分析、精子试验和体细胞变异检测。从设计和解释的角度对苯、氯乙烯单体和环氧氯丙烷的职业研究进行了批判性的讨论。得出的结论是，目前这些测试不适合进行风险评估。其临床相关性（如有）未知。适当的验证和标准化还没有完成，设计问题往往掩盖了以前的研究结果。在职业遗传监测领域迫切需要进一步研究。未来的应用应包括与前瞻性发病率和死亡率研究的整合，设计和统计方法的标准化，以及开发具有遗传相关终点的新试验。
The history and current state of some newer short-term tests for occupational genetic monitoring are reviewed. These are: cytogenetics, sister chromatid exchange, body fluid analysis, tests utilizing sperm, and detection of somatic cell variants. Occupational studies on benzene, vinyl chloride monomer, and epichlorohydrin are critically discussed from the standpoints of design and interpretation. It is concluded that these tests are not appropriate for risk assessment at the present time. Their clinical relevance, if any, is unknown. Proper validation and standardization have not been done, and design problems have often clouded the results of previous studies. There is a critical need for further research in the area of occupational genetic monitoring. Future applications should include integration with prospective morbidity and mortality studies, standardization of design and statistical methods, and development of new tests with genetically relevant endpoints.