Exploring gap junction location and density in electrically coupled hippocampal oriens interneurons
Exploring gap junction location and density in electrically coupled hippocampal oriens interneurons
复制标题
探索电耦合海马方向中间神经元的间隙连接位置和密度
DOI：
10.1016/j.neucom.2005.12.043
复制
发表时间：
2006
期刊：
影响因子：
6
通讯作者：
F. Skinner
中科院分区：
文献类型：
--
作者：
F. Saraga;Xiaolei Zhang;L. Zhang;P. Carlen;F. Skinner
神经元间的网络，连接化学和电（缝隙连接）突触，是重要的塑造群体场的节奏在海马。最近，在海马CA 1区的oriens中间神经元之间发现了微弱的电耦合。一个细胞的动作电位在相连的细胞中产生小穗。我们使用oriens interneurons的两细胞模型网络，以确定树突状的位置和强度的间隙连接需要匹配实验测得的小穗特征。预测差距连接的位置距离索马150-200μm，对应于从索马到树突位置测量的0.17-0.23的电紧张长度和从树突位置到索马测量的0.71-1.04的电紧张长度，电导为500- 800 pS。
Interneuronal networks, connected by chemical and electrical (gap junctions) synapses, are important for shaping population field rhythms in the hippocampus. Recently, weak electrical coupling has been found between oriens interneurons in the CA1 region of the hippocampus. Action potentials in one cell produced spikelets in the connected cell. We use a two-cell model network of oriens interneurons to determine the dendritic location and strength of gap junctions needed to match experimentally measured spikelet characteristics. The location of the gap junctions is predicted to be 150–200μm from the soma, corresponding to electrotonic lengths of 0.17–0.23 as measured from the soma to the dendrite location and 0.71–1.04 as measured from the dendritic location to the soma, with a conductance of 500–800pS.