PILUS-FACILITATED ADHERENCE OF NEISSERIA-MENINGITIDIS TO HUMAN EPITHELIAL AND ENDOTHELIAL-CELLS - MODULATION OF ADHERENCE PHENOTYPE OCCURS CONCURRENTLY WITH CHANGES IN PRIMARY AMINO-ACID-SEQUENCE AND THE GLYCOSYLATION STATUS OF PILIN
PILUS-FACILITATED ADHERENCE OF NEISSERIA-MENINGITIDIS TO HUMAN EPITHELIAL AND ENDOTHELIAL-CELLS - MODULATION OF ADHERENCE PHENOTYPE OCCURS CONCURRENTLY WITH CHANGES IN PRIMARY AMINO-ACID-SEQUENCE AND THE GLYCOSYLATION STATUS OF PILIN
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DOI：
10.1111/j.1365-2958.1993.tb00972.x
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发表时间：
1993-12-01
影响因子：
3.6
通讯作者：
FERGUSON, DJP
中科院分区：
文献类型：
--
作者：
VIRJI, M;SAUNDERS, JR;FERGUSON, DJP
在表达pill的变异体中，促进荚膜脑膜炎奈瑟菌粘附于内皮细胞和上皮细胞。而N.脑膜炎球菌菌株C311大量粘附于内皮细胞（>150个细菌/细胞），含有破坏编码菌毛蛋白亚基的pilE的特异性突变的衍生物都是无纤毛的，并且不能粘附于内皮细胞（
Adherence of capsulate Neisseria meningitidis to endothelial and epithelial cells is facilitated in variants that express pill. Whereas piliated variants of N. meningitidis strain C311 adhered to endothelial cells in large numbers (>150 bacteria/cell), derivatives containing specific mutations that disrupt pilE encoding the pilin subunit were both non-piliated and failed to adhere to endothelial cells (