Congenital Anomalies and Diabetes in the Pima Indians of Arizona
Congenital Anomalies and Diabetes in the Pima Indians of Arizona
复制标题
亚利桑那州皮马印第安人的先天异常和糖尿病
作者：
L. Comess;P. Bennett;T. Burch;M. Miller
对1207名皮马印度儿童的医疗记录进行了检查，以确定是否有报告的先天性异常。在母亲在25岁之前确诊患有糖尿病的21个子女中，有8个(38.1%)出现了异常，但所有其他妇女的子女中只有3.7%出现了异常。糖尿病母亲在25岁或之后发病后所生的孩子，以及糖尿病前期母亲所生的孩子出现异常的频率并不比非糖尿病母亲的孩子高。先天畸形与父系糖尿病无关。在“糖尿病”怀孕期间，母亲需要降血糖药物的孩子比不需要药物治疗的孩子更容易出现异常。尽管不能完全排除遗传机制，但数据更好地支持了这样的假设，即糖尿病通过影响怀孕早期的宫内环境而导致皮马印第安人的胎儿畸形。
Medical records of 1,207 Pima Indian children were examined for reported congenital anomalies. Anomalies occurred in eight (38.1 per cent) of twenty-one offspring born after the onset of diabetes to mothers whose disease was diagnosed before age twenty-five, but in only 3.7 per cent of the offspring of all other women. Children born after the onset of diabetes to mothers whose disease started at or after age twenty-five, and those born to prediabetic mothers had anomalies no more frequently than the children of nondiabetic mothers. Congenital anomalies were not related to paternal diabetes. Anomalies were more frequent in children from “diabetic” pregnancies during which the mother required hypoglycemic medication than from those during which medication was not required. Although a genetic mechanism cannot be completely excluded, the data better support the hypothesis that diabetes produced fetal anomalies among the Pima Indians by its influence upon the intrauterine environment during early pregnancy.