Flexible polyimide-based intracortical electrode arrays with bioactive capability
Flexible polyimide-based intracortical electrode arrays with bioactive capability
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DOI：
10.1109/10.914800
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发表时间：
2001-03-01
影响因子：
4.6
通讯作者：
Kipke, DR
中科院分区：
文献类型：
--
作者：
Rousche, PJ;Pellinen, DS;Kipke, DR
先进的神经假体系统能否显着改善一部分聋哑人、盲人或瘫痪人群的生活质量，取决于为中枢神经系统开发有效、安全的多通道神经接口。提供这种接口的候选植入装置必须超过许多严格的设计参数。我们展示了一种基于聚酰亚胺的薄膜、多通道皮质内 Bio-MEMS 接口，采用标准平面光刻 CMOS 兼容技术在 4 英寸硅晶圆上制造。聚酰亚胺的使用提供了一种机械柔性基板，可以将其操纵成独特的三维设计。聚酰亚胺还为将各种重要的生物活性物质选择性附着到装置上提供了理想的表面，以促进组织-电极界面处的有利的长期反应。结构具有集成聚酰亚胺电缆，为高密度连接器提供有效的接触点。该报告详细介绍了这些阵列的生物、电气和机械特性的体内和体外装置表征。结果表明，这些阵列可能是长期神经植入的候选装置。
The promise of advanced neuroprosthetic systems to significantly improve the quality of life for a segment of the deaf, blind, or paralyzed population hinges on the development of an efficacious, and safe, multichannel neural interface for the central nervous system, The candidate implantable device that is to provide such an interface must exceed a host of exacting design parameters. We present a thin-film, polyimide-based, multichannel intracortical Bio-MEMS interface manufactured with standard planar photo-lithographic CMOS-compatible techniques on 4-in silicon wafers. The use of polyimide provides a mechanically flexible substrate which can be manipulated into unique three-dimensional designs. Polyimide also provides an ideal surface for the selective attachment of various important bioactive species onto the device in order to encourage favorable long-term reactions at the tissue-electrode interface. Structures have an integrated polyimide cable providing efficient contact points for a high-density connector. This report details in vivo and in vitro device characterization of the biological, electrical and mechanical properties of these arrays. Results suggest that these arrays could be a candidate device for long-term neural implants.